Table 1 List of upregulated pY peptides in response to the intercellular crosstalk

ASAyYPSSFPK

TMEM119

Transmembrane protein 119

Only in Co-cultured

CCCIyEKPR

PPP1R11

Protein phosphatase 1, regulatory (inhibitor) subunit 11

Only in Co-cultured

0.36

DIYETDyYRK

IIGF1R

Insulin receptor|| insulin-like growth factor 1 receptor

Only in Co-cultured

FGyHIIMVEGR

PIN4

Peptidylprolyl cis/trans isomerase, NIMA-interacting 4

Only in Co-cultured

GASQAGMtGYGRPR

TAGLN

Transgelin

Only in Co-cultured

GIVVyTGDR

ATP1A1

ATPase, Na +/K + transporting, alpha 1 polypeptide

Only in Co-cultured

GKSDPyHATSGALSPAK

GJA1

Gap junction protein, alpha 1, 43 kDa

Only in Co-cultured

GSTAENAEyLR

EGFR

Epidermal growth factor receptor

Only in Co-cultured

1.94

IEKIGEGtyGVVYK

CDK1

Cyclin-dependent kinase 1

Only in Co-cultured

IGEGTYGVVyKGR

CDK1

Cyclin-dependent kinase 1

Only in Co-cultured

0.91

IGEGTyGVVYKGR

CDK1

Cyclin-dependent kinase 1

Only in Co-cultured

1.00

IGVVGGCQEyTGAPYFAAISALK

CARKD

Carbohydrate kinase domain containing

Only in Co-cultured

LVQAAQMLQSDPYsVPAR

VCL

Vinculin

Only in Co-cultured

NTPyKTLEPVKPPTVPNDYMTSPAR

ABI1

Abl-interactor 1

Only in Co-cultured

NVPEIAVYPAFEAPPQYVLPTyEMAVK

LAPTM4A

Lysosomal protein transmembrane 4 alpha

Only in Co-cultured

NVPEIAVYPAFEAPPQYVLPtYEMAVK

LAPTM4A

Lysosomal protein transmembrane 4 alpha

Only in Co-cultured

QASEQNWANySAEQNR

GJA1

Gap junction protein, alpha 1, 43 kDa

Only in Co-cultured

QPAPKPEPSFSEYAsVQVPR

SIRPA

Signal-regulatory protein alpha

Only in Co-cultured

QPAPKPEPSFSEyASVQVPR

SIRPA

Signal-regulatory protein alpha

Only in Co-cultured

QQPTQFINPETPGyVGFANLPNQVHR

SPET2

Septin 2

Only in Co-cultured

QSPEDVyFSKSEQLKPLK

EPHA2

EPH receptor A2

Only in Co-cultured

0.95

SLyDRPASyKK

PDGFRA

Platelet-derived growth factor receptor, alpha polypeptide

Only in Co-cultured

VVQEYIDAFSDyANFK

PTPRA

Protein tyrosine phosphatase, receptor type, A

Only in Co-cultured

1.06

YEMASNPLyR

ITGB5

Integrin, beta 5

Only in Co-cultured

TYVDPHTyEDPNQAVLK

EPHA2

EPH receptor A2

6.60

1.29

KTPQGPPEIySDTQFPSLQSTAK

CDV3

CDV3 homolog (mouse)

5.16

0.51

GSHQISLDNPDyQQDFFPK

EGFR

Epidermal growth factor receptor

4.16

0.93

IGEGTYGVVyK

CDK3|| CDK2|| CDK1

Cyclin-dependent kinase1,2,,3

4.04

1.20

EATQPEPIyAESTK

SGK223

Homolog of rat pragma of Rnd2__

3.22

0.95

IGEGTyGVVYK

CDK3|| CDK2|| CDK1

Cyclin-dependent kinase1,2,,3

3.04

IEKIGEGtYGVVYK

CDK1

Cyclin-dependent kinase 1

2.99

STLQDSDEySNPAPLPLDQHSR

LPXN

Leupaxin

2.86

IEKIGEGTyGVVYK

CDK1

Cyclin-dependent kinase 1

2.82

IGEGTyGTVFK

CDK5

Cyclin-dependent kinase 5

2.77

0.79

VLEDDPEATyTTSGGKIPIR

EPHA2

EPH receptor A2

2.29

1.30

NSFNNPAyYVLEGVPHQLLPPEPPSPAR

INPPL1

Inositol polyphosphate phosphatase-like 1

2.28

0.00

TTEDEVHICHNQDGySYPSR

LDLR

Low density lipoprotein receptor

2.24

1.67

NTyNQTALDIVNQFTTSQASR

CASKIN2

CASK interacting protein 2

2.09

1.27

AGKGESAGyMEPYEAQR

SHB

Src homology 2 domain containing adaptor protein B

Only in Co-cultured

AHAWPSPYKDyEVKK

GPRC5A

G protein-coupled receptor, class C, group 5, member A

Only in Co-cultured

DKVTIADDySDPFDAKNDLK

SHB

Src homology 2 domain containing adaptor protein B

Only in Co-cultured

GRGEyFAIK

PRKCD

Protein kinase C, delta

Only in Co-cultured

GySFTTTAER

ACTG1|| ACTB

Actin gamma 1|| actin, beta

Only in Co-cultured

HTDDEMTGYVAtR

MAPK14

Mitogen-activated protein kinase 14

Only in Co-cultured

LDTASSNGYQRPGsVVAAK

ARHGAP42

Rho GTPase activating protein 42

Only in Co-cultured

LKQPADCLDGLyALMSR

AXL

AXL receptor tyrosine kinase

Only in Co-cultured

NIySDIPPQVPVRPISYTPSIPSDSR

FAT1

FAT atypical cadherin 1

Only in Co-cultured

NNYALNTTATYAEPYRPIQyR

PKP4

Plakophilin 4

Only in Co-cultured

YLNRNyWEK

HGS

Hepatocyte growth factor-regulated tyrosine kinase substrate

Only in Co-cultured

DIHHIDyYKK

FGFR1

Fibroblast growth factor receptor 1

0.98

19.26

YCRPESQEHPEADPGSAAPyLK

STAT3

Signal transducer and activator of transcription 3

0.98

7.03

SEQLKPLKTyVDPHTYEDPNQAVLK

EPHA2

EPH receptor A2

5.60

YCRPESQEHPEADPGAAPyLK

STAT3

Signal transducer and activator of transcription 3

0.86

4.89

NSNSYGIPEPAHAyAQPQTTTPLPAVsGSPGAAITPLPSTQNGPVFAK

CRKL

v-crk avian sarcoma virus CT10 oncogene homolog-like

2.49

STyTSYPK

HGS

Hepatocyte growth factor-regulated tyrosine kinase substrate

1.46

2.33