CD44 glycoprotein in cancer: a molecular conundrum hampering clinical applications

Table 1 Proposed CD44 nomenclature for experimentally observed isoforms, its correspondence with UniProt and NCBI databases and predicted N- and O-glycosylation sites

Proposed nomenclature	UniProt	NCBI	Predicted glycosylation sites
Proposed nomenclature	UniProt	NCBI	N-glycosylation^a	O-glycosylation^b	Total
CD44v2-10	Isoform 1	Isoform 1	8	146	154
CD44v3-10	Isoform 4	Isoform 2	8	133	141
CD44v8-10	Isoform 10	Isoform 3	7	79	86
CD44v10	Isoform 11	Isoform 6	7	56	63
CD44s	Isoform 12	Isoform 4	6	32	38
CD44st	Isoform 15	Isoform 8	6	32	38
CD44s-exon 15	Isoform 18	Isoform 7	6	23	29
CD44soluble	Isoform 19	Isoform 5	2	3	5

^aN-glycosylation sites predicted using NetNGlyc server 1.0 (http://www.cbs.dtu.dk/services/NetNGlyc/)
^bO-glycosylation sites predicted using NetOGlyc server 4.0 (http://www.cbs.dtu.dk/services/NetOGlyc/)

ISSN: 1559-0275