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Table 2 Intraclass correlation coefficient (ICC) and within- and between-subjects variability of urinary MALDI-TOF/MS peptidomic profiling, calculated using different normalization strategies

From: MALDI-TOF peptidomic analysis of serum and post-prostatic massage urine specimens to identify prostate cancer biomarkers

 

ICC (median and IQR)

Within subjects variability (median and IQR)

Between-subjects variability (median and IQR)

Non-normalized features

0.36 (0.24–0.47)

1266 (606–411,000)

739 (198–420,600)

Median normalized features

0.45 (0.26–0.62)

0.140 (0.03–2.38)

0.158 (0.033–3.103)

Creatinine normalized features

0.45 (0.32–0.60)

26.9 (6.5–325.5)

34.6 (6.40–264.12)

sLOD adjusted, Median normalized, log2 transformed features (sLMNLT features)

0.48 (0.32–0.65)

0.184 (0.12–0.33)

0.225 (0.08–0.43)

sLOD adjusted, Creatinine normalized, log2 transformed features

0.35 (0.24–0.47)

0.479 (0.350–0.687)

0.422 (0.335–0.619)

  1. Median values and interquartile ranges (IQR) are outlined