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Table 2 Higher abundant sperm proteins in normozoospermic samples that achieved pregnancy undergoing R-ICSI after IVF failure (n = 36)

From: iTRAQ-based analysis of sperm proteome from normozoospermic men achieving the rescue-ICSI pregnancy after the IVF failure

Swiss-Prot accession number

Protein name

Ratio (Mean ± SD) R-ICSI pregnancy/IVF pregnancy

P62805

Histone H4

2.62 ± 0.03

O95996

Adenomatous polyposis coli protein 2

2.29 ± 0.12

Q8NCQ7

Protein PROCA1

2.13 ± 0.12

P04554

Protamine-2

1.97 ± 0.12

P19652

Alpha-1-acid glycoprotein 2

1.93 ± 0.38

P02766

Transthyretin

1.77 ± 0.10

P63167

Dynein light chain 1

1.72 ± 0.09

Q13200

26S proteasome non-ATPase regulatory subunit 2

1.66 ± 0.23

P02749

Beta-2-glycoprotein 1

1.57 ± 0.11

P31937

3-hydroxyisobutyrate dehydrogenase

1.56 ± 0.01

O14556

Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1.55 ± 0.02

P02763

Alpha-1-acid glycoprotein 1

1.54 ± 0.21

P02760

Protein AMBP

1.53 ± 0.04

P55064

Aquaporin-5

1.53 ± 0.11

Q9Y4G6

Talin-2

1.52 ± 0.20

P38567

Hyaluronidase PH-20

1.51 ± 0.07

Q6UWM5

GLIPR1-like protein 1

1.49 ± 0.13

P25786

Proteasome subunit alpha type-1

1.48 ± 0.11

Q9BYD9

Actin-related protein T3

1.48 ± 0.16

P02765

Alpha-2-HS-glycoprotein

1.47 ± 0.07

P04217

Alpha-1B-glycoprotein

1.45 ± 0.10

P02790

Hemopexin

1.44 ± 0.08

P25311

Zinc-alpha-2-glycoprotein

1.44 ± 0.08

P49748

Very long-chain specific acyl-CoA dehydrogenase

1.43 ± 0.08

Q68DN1

Uncharacterized protein C2orf16

1.42 ± 0.13

Q9BZW7

Testis-specific gene 10 protein

1.40 ± 0.03

Q96FJ2

Dynein light chain 2

1.39 ± 0.03

Q71DI3

Histone H3.2

1.39 ± 0.10

A6NMS7

Leucine-rich repeat-containing protein 37A

1.39 ± 0.07

P43652

Afamin

1.32 ± 0.03

Q8N0W7

Fragile X mental retardation 1 neighbor protein

1.32 ± 0.14

P49721

Proteasome subunit beta type-2

1.31 ± 0.07

Q5VZ72

Izumo sperm-egg fusion protein 3

1.30 ± 0.13

Q96QV6

Histone H2A type 1-A

1.29 ± 0.22

Q96KR1

Zinc finger RNA-binding protein

1.29 ± 0.10

P38117

Electron transfer flavoprotein subunit beta

1.28 ± 0.12

  1. Annotations of altered proteins identified in sperm samples from the R-ICSI pregnancy group compared with the IVF pregnancy group. Values > 1.274 (P < 0.05) correspond to higher abundance in the R-ICSI pregnancy group. Standard deviation (SD)