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Table 1 Differential induction of major outer membrane proteins of Acinetobacter baumannii DU202 OMV according to imipenem treatment

From: Antibiotic treatment modulates protein components of cytotoxic outer membrane vesicles of multidrug-resistant clinical strain, Acinetobacter baumannii DU202

Locus_tag

Description

Localization

Log ratioa

OMVLBb

OMVimipenemb

DU202_RS06415

Carbapenem-hydrolyzing class D beta-lactamase OXA-23

Cytoplasmic

0.923

4.3782

36.682

DU202_RS02680

Tail-specific protease

OuterMembrane

0.855

0.037

0.262

DU202_RS15465

Lipoprotein NlpD

Periplasmic

0.69

0.051

0.251

DU202_RS16100

Tol–Pal system beta propeller repeat protein TolB

OuterMembrane

0.53

0.168

0.57

DU202_RS19805

Transporter

OuterMembrane

0.461

0.078

0.225

DU202_RS12145

Outer membrane protein assembly factor BamA

OuterMembrane

0.46

0.111

0.319

DU202_RS11840

TonB-dependent siderophore receptor

OuterMembrane

0.439

0.045

0.123

DU202_RS15930

Putative serine protease

OuterMembrane

0.413

0.326

0.844

DU202_RS18760

Superoxide dismutase (Cu–Zn)

Periplasmic

0.366

0.762

1.77

DU202_RS20255

M23 family peptidase

Periplasmic

0.365

0.051

0.119

DU202_RS01660

Outer membrane protein W precursor

Periplasmic

0.265

0.49

0.903

DU202_RS04315

Outer membrane protein assembly factor BamD

OuterMembrane

0.244

0.106

0.186

DU202_RS17430

Outer membrane protein A precursor

OuterMembrane

0.196

1.775

2.789

DU202_RS00390

FKBP-type peptidyl-prolyl cis–trans isomerase

OuterMembrane

0.178

0.083

0.125

DU202_RS10675

Putative bacteriophage Mu Gp45 protein

Periplasmic

− 0.579

0.112

0.03

DU202_RS16695

Succinate dehydrogenase flavoprotein subunit

Cytoplasmic

− 0.586

0.158

0.041

DU202_RS17820

Preprotein translocase subunit YajC

InnerMembrane

− 0.592

0.18

0.046

DU202_RS14050

Phage head–tail adapter protein

Cytoplasmic

− 0.61

0.149

0.037

DU202_RS09385

Phage major capsid protein

Periplasmic

− 0.632

1.084

0.253

DU202_RS04220

Peptidoglycan-binding protein LysM

Periplasmic

− 0.7

0.12

0.024

DU202_RS05710

Copper resistance protein NlpE

Extracellular

− 0.743

0.447

0.081

DU202_RS09380

HK97 family phage prohead protease

Cytoplasmic

− 0.75

0.214

0.038

DU202_RS10720

Phage tail sheath-like protein

Periplasmic

− 0.767

0.175

0.03

DU202_RS13995

Lytic transglycosylase domain-containing protein

OuterMembrane

− 0.8

0.16

0.025

DU202_RS14000

Methyl-coenzyme M reductase

OuterMembrane

− 0.967

0.482

0.052

DU202_RS16690

Succinate dehydrogenase iron-sulfur subunit

Cytoplasmic

− 1.307

0.154

0.008

DU202_RS09375

Phage portal protein

OuterMembrane

− 1.522

0.718

0.022

  1. aInduction ratio was calculated as OMVLB per OMVIM
  2. bAbundance was indicated as mol%