Table 2 The summary of STRING analysis with respect to a random sampling of the human genome for gene symbols that show a Chi Square (χ2) value ≥ 15 (see Additional file 1: Table S1, Additional file 2: Table S2)
Pathway ID | Pathway description | Count in gene set | False discovery rate |
|---|---|---|---|
Biological process (GO) | |||
GO:0007017 | Microtubule-based process | 17 | 0.00251 |
GO:0007018 | Microtubule-based movement | 11 | 0.00251 |
GO:1902589 | Single-organism organelle organization | 34 | 0.0265 |
Molecular function (GO) | |||
GO:0003774 | Motor activity | 12 | 3.17E−06 |
GO:0003777 | Microtubule motor activity | 9 | 2.55E−05 |
GO:0043167 | Ion binding | 81 | 0.000114 |
GO:0032559 | Adenyl ribonucleotide binding | 30 | 0.00325 |
GO:0097159 | Organic cyclic compound binding | 71 | 0.00325 |
GO:1901363 | Heterocyclic compound binding | 70 | 0.00325 |
GO:0005524 | ATP binding | 29 | 0.004 |
GO:0036094 | Small molecule binding | 41 | 0.00734 |
GO:0005515 | Protein binding | 60 | 0.00741 |
GO:0005488 | Binding | 107 | 0.0114 |
GO:0043169 | Cation binding | 56 | 0.0114 |
GO:0016887 | ATPase activity | 12 | 0.0122 |
GO:0046872 | Metal ion binding | 55 | 0.0122 |
GO:0043168 | Anion binding | 40 | 0.014 |
GO:0032549 | Ribonucleoside binding | 30 | 0.0393 |
GO:0000166 | Nucleotide binding | 35 | 0.0419 |
Cellular component (GO) | |||
GO:0005875 | Microtubule associated complex | 10 | 0.000239 |
GO:0072562 | Blood microparticle | 9 | 0.000239 |
GO:0032991 | Macromolecular complex | 62 | 0.00102 |
GO:0015630 | Microtubule cytoskeleton | 23 | 0.00182 |
GO:0043233 | Organelle lumen | 57 | 0.00182 |
GO:0044446 | Intracellular organelle part | 86 | 0.00317 |
GO:0044430 | Cytoskeletal part | 26 | 0.00399 |
GO:0030286 | Dynein complex | 5 | 0.0049 |
GO:0044422 | Organelle part | 86 | 0.00587 |
GO:0030426 | Growth cone | 7 | 0.00767 |
GO:0043232 | Intracellular non-membrane-bounded organelle | 48 | 0.00767 |
GO:0070013 | Intracellular organelle lumen | 53 | 0.00771 |
GO:0005868 | Cytoplasmic dynein complex | 4 | 0.0102 |
GO:0005858 | Axonemal dynein complex | 3 | 0.0174 |
GO:0043226 | Organelle | 116 | 0.0174 |
GO:0043234 | Protein complex | 50 | 0.0174 |
GO:0097513 | Myosin II filament | 2 | 0.0174 |
GO:0043229 | Intracellular organelle | 109 | 0.0203 |
GO:0005856 | Cytoskeleton | 29 | 0.0272 |
GO:0030027 | Lamellipodium | 7 | 0.0272 |
GO:0031988 | Membrane-bounded vesicle | 45 | 0.0272 |
GO:0033553 | rDNA heterochromatin | 2 | 0.0272 |
GO:0071682 | Endocytic vesicle lumen | 3 | 0.0272 |
GO:0071013 | Catalytic step 2 spliceosome | 5 | 0.0299 |
GO:0001725 | Stress fiber | 4 | 0.0301 |
GO:0044441 | Ciliary part | 9 | 0.0315 |
GO:0070062 | Extracellular exosome | 38 | 0.0318 |
GO:0005929 | Cilium | 11 | 0.0325 |
GO:0060205 | Cytoplasmic membrane-bounded vesicle lumen | 5 | 0.0325 |
GO:0005874 | Microtubule | 10 | 0.0331 |
GO:0005654 | Nucleoplasm | 38 | 0.0343 |
GO:0005871 | Kinesin complex | 4 | 0.0353 |
GO:0042641 | Actomyosin | 4 | 0.0353 |
GO:0043227 | Membrane-bounded organelle | 109 | 0.0363 |
GO:0042995 | Cell projection | 25 | 0.0441 |
GO:0044463 | Cell projection part | 16 | 0.0441 |
KEGG pathways | |||
5205 | Proteoglycans in cancer | 11 | 0.000747 |
Molecular function (GO) | |||
GO:0003774 | Motor activity | 12 | 9.83E−06 |
GO:0032559 | Adenyl ribonucleotide binding | 34 | 0.000836 |
GO:0005524 | ATP binding | 33 | 0.000971 |
GO:0000166 | Nucleotide binding | 42 | 0.00237 |
GO:0032550 | Purine ribonucleoside binding | 36 | 0.00237 |
GO:0032555 | Purine ribonucleotide binding | 36 | 0.00237 |
GO:0036094 | Small molecule binding | 45 | 0.00237 |
GO:0043168 | Anion binding | 46 | 2.37E−03 |
GO:0035639 | Purine ribonucleoside triphosphate binding | 35 | 3.07E−03 |
GO:0097367 | Carbohydrate derivative binding | 39 | 0.00529 |
GO:0043167 | Ion binding | 78 | 0.0171 |
GO:0031267 | Small gtpase binding | 8 | 0.0221 |
GO:0008092 | Cytoskeletal protein binding | 14 | 0.0392 |
GO:0017111 | Nucleoside-triphosphatase activity | 17 | 0.0417 |
GO:0005219 | Ryanodine-sensitive calcium-release channel activity | 2 | 0.0462 |
Cellular component (GO) | |||
GO:0016459 | Myosin complex | 8 | 0.000231 |
GO:0005737 | Cytoplasm | 114 | 0.00491 |
GO:0005856 | Cytoskeleton | 35 | 0.00491 |
GO:0042995 | Cell projection | 32 | 0.00491 |
GO:0043232 | Intracellular non-membrane-bounded organelle | 54 | 0.00491 |
GO:0016461 | Unconventional myosin complex | 3 | 0.00638 |
GO:0072562 | Blood microparticle | 7 | 0.0127 |
GO:0005874 | Microtubule | 12 | 0.0176 |
GO:0030016 | Myofibril | 9 | 0.0176 |
GO:0044430 | Cytoskeletal part | 25 | 0.0315 |
GO:0097458 | Neuron part | 22 | 0.0315 |
GO:0097513 | Myosin II filament | 2 | 0.0315 |
GO:0044449 | Contractile fiber part | 8 | 0.0449 |
GO:0015630 | Microtubule cytoskeleton | 20 | 0.0462 |
GO:0044463 | Cell projection part | 18 | 0.0462 |
GO:0071682 | Endocytic vesicle lumen | 3 | 0.0462 |
GO:0043005 | Neuron projection | 18 | 0.0472 |