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Table 3 p-values for the individual proteins in the discovery and replication steps in the comparison of endometrial cancer to benign tumors, population controls and ovarian cancer

From: A two-step strategy for identification of plasma protein biomarkers for endometrial and ovarian cancer

Uniprot no

Uniprot protein name

Proseek protein ID

Cancer

Endometrial cancer versus benign cysts

Endometrial cancer versus ovarian cancer 1–4

Endometrial cancer versus population controls

Discovery

Replication

Discovery

Replication

Discovery

Replication

Q16651

Prostasin

CVD2_173_PRSS8

OE

4.36E−09

6.88E−08

1

3.22E−07

0.01381015

0.928202706

P21741

Midkine

ONC2_161_MK

OE

3.65E−08

0.119795419

1

8.20E−09

0.026477007

1

Q14508

Major epididymis-specific protein E4 (WAP four-disulfide core domain protein 2)

ONC2_182_WFDC2

OE

6.28E−09

1.71E−10

1

2.83E−12

0.290677608

0.00019993

P22301

Interleukin 10

INF_162_IL-10

OE

4.23E−12

1

1

1

0.065101325

1

P35318

Adenomedulin

CVD2_103_ADM

E

2.48E−07

0.004662956

0.005277639

1

5.23E−05

0.608471686

P35475

Al pha-L-iduronidase

CVD2_116_IDUA

E

1.05E−05

0.954600936

6.83E−10

1

6.52E−08

0.443914788

P09237

Matrilysin

CVD2_167_MMP-7

E

7.21E−06

0.000194133

1

0.112528602

0.001380847

0.000174466

P15090

Fatty acid-binding protein, adipocyte

CVD3_129_FABP4

E

1.10E−06

1

0.01262521

1

0.000231174

0.023151067

Q8NBP7

Proprotein convertase subtilisin/kexin type 9

CVD3_161_PCSK9

E

1.43E−05

1

2.42E−05

1

0.002207816

1

Q01638

Interleukin-1 receptor-like 1

CVD3_176_ST2

E

1.35E−06

0.010291606

0.023539896

1

0.000249695

0.242686447

Q9UBR2

Cathepsin Z

CVD3_185_CTSZ

E

3.20E−07

1

3.59E−06

1

2.28E−06

1

015467

C–C motif chemokine 16

CVD3_196_CCL16

E

2.70E−06

1

0.48003849

0.006484386

0.005950521

1

Q9UBT3

Dickkopf-related protein 4

NEU_187_Dkk-4

E

2.60E−09

1

4.27E−05

0.252055749

0.000134061

0.022042978

P15692

Vascular endothelial growth factor A

INF_102_VEGF-A

E

0.00150827

1.88E−06

1

4.56E−05

0.156267791

1

P05231

Interleukin-6

INF_113_IL-6

E

0.000735048

1.41E−05

1

5.49E−06

1

1

P08581

Hepatocyte growth factor receptor

INF_156_HGF

E

6.46E−05

6.46E−05

6.46E−05

6.46E−05

6.46E−05

0.010198277

  1. NA not applicable