A two-step strategy for identification of plasma protein biomarkers for endometrial and ovarian cancer

Enroth, Stefan; Berggrund, Malin; Lycke, Maria; Lundberg, Martin; Assarsson, Erika; Olovsson, Matts; Stålberg, Karin; Sundfeldt, Karin; Gyllensten, Ulf

doi:10.1186/s12014-018-9216-y

Clinical Proteomics

Table 4 Estimates of sensitivity and specificity for the protein panel based on the discovery and replication data

From: A two-step strategy for identification of plasma protein biomarkers for endometrial and ovarian cancer

Comparison	Proteins	Best point				AUC	Minimum specificity of 0.95 (screening)				Minimum sensitivity of 0.95 (diagnostic)
		Sensitivity		Specificity			Sensitivity		Specificity		Sensitivity		Specificity
		Mean	SD	Mean	SD		Mean	SD	Mean	SD	Mean	SD	Mean	SD
Analysis discovery
Benign tumors versus ovarian cancer stage I–II	All	0.68	0.07	0.73	0.08	0.72	0.33	0.11	0.96	0.01	0.96	0.01	0.07	0.08
Benign tumors versus ovarian cancer stage III–IV	All	0.93	0.04	0.93	0.03	0.95	0.86	0.07	0.96	0.01	0.96	0.00	0.54	0.25
Benign tumors versus ovarian cancer stage I–IV	All	0.79	0.04	0.85	0.04	0.86	0.61	0.07	0.96	0.01	0.96	0.01	0.18	0.10
Population ontrols versus ovarian cancer stage I–II	All	0.70	0.07	0.75	0.07	0.74	0.43	0.07	0.96	0.01	0.97	0.01	0.02	0.05
Population controls versus ovarian cancer stage III–IV	All	0.94	0.03	0.96	0.03	0.97	0.92	0.05	0.96	0.01	0.97	0.01	0.47	0.29
Population controls versus ovarian stage I–IV	All	0.75	0.05	0.87	0.05	0.86	0.66	0.06	0.95	0.00	0.96	0.01	0.13	0.10
Benign tumors versus endometrial cancer	All	0.77	0.05	0.79	0.05	0.83	0.45	0.11	0.96	0.01	0.97	0.01	0.09	0.11
Population controls versus endometrial cancer	All	0.69	0.06	0.78	0.06	0.76	0.43	0.07	0.95	0.00	0.97	0.01	0.07	0.07
Ovarian cancer versus endometrial cancer	All	0.84	0.04	0.88	0.04	0.89	0.64	0.17	0.97	0.01	0.96	0.01	0.42	0.16
Replication
Benign tumors versus ovarian cancer stage I–II	All	0.73	0.08	0.74	0.07	0.76	0.29	0.11	0.97	0.01	0.97	0.01	0.19	0.14
Benign tumors versus ovarian cancer stage III–IV	All	0.88	0.03	0.92	0.03	0.92	0.81	0.07	0.96	0.01	0.96	0.01	0.58	0.15
Benign tumors versus ovarian cancer stage I–IV	All	0.83	0.04	0.87	0.04	0.89	0.68	0.10	0.97	0.01	0.96	0.01	0.48	0.12
Population ontrols versus ovarian cancer stage I–II	All	0.62	0.09	0.68	0.11	0.63	0.24	0.12	0.97	0.01	0.97	0.01	0.06	0.10
Population controls versus ovarian cancer stage III–IV	All	0.85	0.03	0.92	0.04	0.89	0.78	0.09	0.97	0.01	0.96	0.01	0.35	0.15
Population controls versus ovarian stage I–IV	All	0.77	0.05	0.85	0.05	0.86	0.62	0.10	0.96	0.01	0.96	0.01	0.21	0.11
Benign tumors versus endometrial cancer	All	0.70	0.06	0.67	0.07	0.72	0.22	0.09	0.97	0.01	0.96	0.01	0.25	0.08
Population controls versus endometrial cancer	All	0.64	0.07	0.72	0.08	0.71	0.24	0.14	0.97	0.01	0.96	0.01	0.10	0.06
Ovarian cancer versus endometrial cancer	All	0.73	0.03	0.77	0.04	0.78	0.36	0.06	0.96	0.00	0.96	0.00	0.11	0.06
Benign tumors versus ovarian cancer stage I–II	CA125/HE4	0.73	0.08	0.73	0.07	0.78	0.38	0.11	0.97	0.01	0.97	0.01	0.30	0.16
Benign tumors versus ovarian cancer stage III–IV	CA125/HE4	0.87	0.03	0.87	0.04	0.90	0.74	0.06	0.97	0.02	0.96	0.01	0.37	0.12
Benign tumors versus ovarian cancer stage I–IV	CA125/HE4	0.79	0.03	0.87	0.04	0.87	0.67	0.06	0.97	0.01	0.96	0.01	0.39	0.10
Population ontrols versus ovarian cancer stage I–II	CA125/HE4	0.59	0.08	0.77	0.10	0.66	0.35	0.11	0.97	0.01	0.97	0.01	0.14	0.07
Population controls versus ovarian cancer stage III–IV	CA125/HE4	0.84	0.03	0.89	0.04	0.86	0.74	0.07	0.97	0.01	0.96	0.00	0.17	0.09
Population controls versus ovarian stage I–IV	CA125/HE4	0.77	0.03	0.88	0.05	0.81	0.65	0.08	0.96	0.00	0.96	0.01	0.14	0.07

Back to article page

ISSN: 1559-0275

Contact us

Submission enquiries: journalsubmissions@springernature.com