High accuracy differentiating autoimmune pancreatitis from pancreatic ductal adenocarcinoma by immunoglobulin G glycosylation

Table 1 Summary of glycosylation changes in autoimmune pancreatitis (AIP) and pancreatic ductal adenocarcinoma (PDAC)

Glycoforms	AIP versus control	P value	AIP versus PDAC	P-value	PDAC versus control	P-value
Fucosylation of IgG1	↑	P < 0.001	↑	P < 0.001	↓	P < 0.001
Bisecting GlcNAc of IgG1	↓	P < 0.001	↓	P < 0.001	NS	–
Agalactosylation of IgG1	NS	–	↓	P < 0.001	↑	P < 0.001
Sialylation of IgG1	NS	–	↑	P < 0.001	↓	P < 0.05
Galactosylation of IgG1	NS	–	↑	P < 0.001	NS	–
Sialylation ratio of IgG1	↑	P < 0.05	↑	P < 0.001	NS	–
Sialylation ratio of IgG2	↑	P < 0.001	↑	P < 0.001	NS	–
Sialylation ratio of IgG4	↑	P < 0.001	↑	P < 0.001	NS	–
Agalactosylation ratio of IgG1	NS	–	↓	P < 0.05	↑	P < 0.001
Agalactosylation ratio of IgG2	NS	–	↓	P < 0.001	↑	P < 0.01
Agalactosylation ratio of IgG4	↑	P < 0.001	NS	–	↑	P < 0.001

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