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Table 3 Glycoforms in the autoimmune pancreatitis patients with and without hepatobiliary involvement

From: High accuracy differentiating autoimmune pancreatitis from pancreatic ductal adenocarcinoma by immunoglobulin G glycosylation

Glycoform

Without hepatobiliary involvement

With hepatobiliary involvement

P

Galactosylation of IgG1 (%)

62.52 ± 5.73

59.33 ± 1.39

0.032*

Agalactosylation of IgG1 (%)

15.49 ± 4.63

18.56 ± 6.23

0.015*

Bisected glycoforms of IgG1 (%)

26.48 ± 5.87

29.42 ± 7.61

0.061

Sialylation of IgG1 (%)

20.49 ± 4.86

21.45 ± 8.71

0.481

Fucosylated of IgG1 (%)

85.86 ± 3.51

85.95 ± 3.69

0.920

Agalactosylation ratio

 Agalactosylation ratio of IgG1

0.83 ± 0.43

1.06 ± 0.54

0.042*

 Agalactosylation ratio of IgG2

0.79 ± 0.33

0.98 ± 0.36

0.021*

 Agalactosylation ratio of IgG4

1.41 ± 0.84

1.35 ± 0.62

0.721

Sialylation ratio

 Sialylation ratio of IgG1

0.78 ± 0.36

1.00 ± 0.57

0.038*

 Sialylation ratio of IgG2

0.72 ± 0.42

0.78 ± 0.41

0.540

 Sialylation ratio of IgG4

1.48 ± 0.76

1.83 ± 1.21

0.017*

Summation

 Agalactosylation ratio of IgG1 and agalactosylation ratio of IgG4

0.24 ± 0.15

2.54 ± 0.24

0.289

 Sialylation ratio of IgG2 and sialylation ratio of IgG4

2.07 ± 0.11

2.21 ± 0.12

0.038*

 Sialylation ratio of IgG1, sialylation ratio of IgG2, and sialylation ratio of IgG4

2.8 ± 0.14

3.05 ± 0.15

0.028*

  1. Galactosylation (%): (G1 + G1F + G1FN + G1N + G1S + G1FS1) * 0.5 + G2 + G2F + G2FN + G2N + G2S1 + G2/total IgG1; agalactosylation (%): G0F + G0FN + G0N + G0/total IgG1; bisected glycoforms (%): G0N + G1N + G2N + G0FN + G1FN + G2FN/total IgG1; sialylation of IgG1 (%): G1FS1 + G2S1 + G2FS1 + G1S/total IgG1; fucosylation (%): G0F + G0FN + G1F + G1FN + G1FS1 + G2F + G2FN + G2FS1/total IgG1
  2. *P < 0.05; **P < 0.01; ***P < 0.001
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Clinical Proteomics

ISSN: 1559-0275