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Table 4 Glycoforms in the early and advanced stages of pancreatic ductal adenocarcinoma

From: High accuracy differentiating autoimmune pancreatitis from pancreatic ductal adenocarcinoma by immunoglobulin G glycosylation

Glycoforms

Cancer stage

Patients’ survival

Early

Advanced

P

Top 25% percentile of survival

Ordinary

P

Galactosylation of IgG1 (%)

61.66 ± 5.26

58.02 ± 4.07

0.007*

59.67 ± 4.16

57.93 ± 4.29

0.060

Agalactosylation of IgG1 (%)

17.38 ± 4.54

20.24 ± 4.42

0.044*

19.24 ± 4.31

20.21 ± 4.55

0.317

Bisected glycoforms of IgG1 (%)

29.58 ± 6.42

31.81 ± 5.71

0.226

30.21 ± 5.35

32.06 ± 5.89

0.140

Sialylation of IgG1 (%)

16.97 ± 5.47

17.54 ± 4.13

0.673

17.61 ± 4.22

17.44 ± 4.29

0.853

Fucosylated of IgG1 (%)

79.40 ± 6.32

81.17 ± 4.17

0.208

79.50 ± 3.97

81.50 ± 4.46

0.034*

Agalactosylation ratio

 Agalactosylation ratio of IgG1

0.93 ± 0.30

1.10 ± 0.62

0.371

0.10 ± 0.38

1.12 ± 0.65

0.351

 Agalactosylation ratio of IgG2

1.01 ± 0.35

1.05 ± 0.48

0.789

1.01 ± 0.40

0.06 ± 0.49

0.651

 Agalactosylation ratio of IgG4

1.08 ± 0.49

1.46 ± 0.80

0.090

1.34 ± 0.53

1.49 ± 0.85

0.370

Sialylation ratio

 Sialylation ratio of IgG1

0.55 ± 0.17

0.58 ± 0.33

0.764

0.49 ± 0.24

0.60 ± 0.33

0.080

 Sialylation ratio of IgG2

0.42 ± 0.22

0.41 ± 0.20

0.865

0.35 ± 0.18

0.43 ± 0.20

0.053

 Sialylation ratio of IgG4

0.81 ± 0.39

0.66 ± 0.42

0.277

0.71 ± 0.48

0.66 ± 0.39

0.641

Summation

 Agalactosylation ratio of IgG1 and agalactosylation ratio of IgG4

2.07 ± 0.25

2.50 ± 0.12

0.026*

2.51 ± 0.18

2.44 ± 0.14

0.782

 Sialylation ratio of IgG2 and sialylation ratio of IgG4

1.57 ± 0.26

1.97 ± 0.11

0.025*

1.76 ± 0.18

1.99 ± 0.12

0.322

 Sialylation ratio of IgG1, sialylation ratio of IgG2, and sialylation ratio of IgG4

2.28 ± 0.33

2.75 ± 0.14

0.030*

2.49 ± 0.23

2.77 ± 0.16

0.359

  1. Early stage: stage I and II
  2. Advanced stage: stage III and IV
  3. Galactosylation of IgG1 (%): (G1 + G1F + G1FN + G1N + G1S + G1FS1) * 0.5 + G2 + G2F + G2FN + G2N + G2S1 + G2/total IgG1; agalactosylation of IgG1 (%): G0F + G0FN + G0N + G0/total IgG1
  4. Bisected glycoforms of IgG1 (%): G0N + G1N + G2N + G0FN + G1FN + G2FN/total IgG1
  5. Sialylation of IgG1 (%): G1FS1 + G2S1 + G2FS1 + G1S/total IgG1
  6. Fucosylation of IgG1 (%): G0F + G0FN + G1F + G1FN + G1FS1 + G2F + G2FN + G2FS1/total IgG1
  7. *P < 0.05; **P < 0.01; ***P < 0.001