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Table 1 Differentially expressed proteins of interest detected by 2D-DIGE that were chosen for evaluation by immunohistochemistry

From: Combination of laser microdissection, 2D-DIGE and MALDI-TOF MS to identify protein biomarkers to predict colorectal cancer spread

No. Gene name Uniprot accession number Protein name Fold change (NM/M)* p value (NM/M) Peptides matched Protein sequence coverage (%)
1 LTBP3 Q9NS15 Latent-transforming growth factor beta binding protein 3 1.7 0.05 19 16
2 HLAB P30475 HLA class 1 histocompatibility antigen, B39 alpha chain 2.5 0.03 8 21
3 ADAMTS2 O95450 A disintegrin and metalloproteinase with thrombospodin motifs 2 1.5 0.01 14 22
4 RECK O95980 Reversion-inducing cysteine-rich protein 1.8 0.03 15 19
5 WNT5A P41221 Wnt-5a protein 0.56 0.06 9 22
6 14-3-3-β P31946 14-3-3 protein beta/alpha 0.67 0.05 9 37
7 SRPX P78539 Sushi repeat-containing protein SRPX 1.5 0.02 14 26
8 NME2 P22392 Nucleoside diphosphate kinase B (nm23H2) 1.6 0.005 8 38
9 MRLC 3 P19105 Myosin regulatory light chain MRLC3 0.67 0.025 7 46
10 JAG2 Q9Y219 Protein Jagged-2 1.7 0.05 23 20
  1. Note: Student’s t test based on log2 transformed spot volumes between non-metastasized (NM) and metastasized (M) tumors
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Clinical Proteomics

ISSN: 1559-0275