Table 2 20 proteins with highest abundance increase and decrease, respectively, in UC patients as compared to healthy controls
From: Ulcerative colitis: functional analysis of the in-depth proteome
Ratio UC/H | Protein name | Gene names | Majority protein ID | − Log p value |
|---|---|---|---|---|
Proteins of increased abundance in UC compared to healthy controls | ||||
10.12 | Kinesin-like protein | KIF26B | B7WPD9 | 10.55 |
6.72 | Protein S100-A8 | S100A8 | P05109 | 8.41 |
6.70 | Cathelicidin antimicrobial peptide | CAMP | J3KNB4 | 9.71 |
6.17 | Protein S100-A9 | S100A9 | P06702 | 8.07 |
4.95 | Protein S100-A12 | S100A12 | P80511 | 8.36 |
4.73 | Neutrophil defensin 1 | DEFA1 | P59665 | 7.02 |
4.47 | Lactotransferrin | LTF;HEL110 | E7EQB2 | 9.42 |
4.39 | Myeloblastin | PRTN3 | P24158 | 7.49 |
4.18 | Neutrophil gelatinase-associated lipocalin | NGAL;LCN2 | B2ZDQ1 | 13.57 |
3.54 | Neutrophil elastase | ELANE;ELA2 | P08246 | 7.48 |
3.51 | Azurocidin | AZU1 | P20160 | 8.36 |
3.49 | Cysteine-rich secretory protein 3 | CRISP3 | J3KPA1 | 6.44 |
3.22 | Myeloperoxidase | MPO | P05164-2 | 9.05 |
3.20 | Bactericidal permeability-increasing protein | BPI | A2NX48 | 4.31 |
3.18 | 60S ribosomal protein L14 | RPL14 | P50914 | 1.62 |
3.17 | Bactericidal permeability-increasing protein | BPI | P17213 | 8.26 |
3.16 | Lysozyme | LYZ | B2R4C5 | 8.50 |
3.12 | Marginal zone B- and B1-cell-specific protein | MZB1 | Q8WU39 | 14.01 |
3.07 | Ig heavy chain V-I region EU | IGHV1-69-2 | P01742 | 3.98 |
3.01 | Ficolin-1 | FCN1 | O00602 | 6.65 |
Proteins of decreased abundance in UC compared to healthy controls | ||||
0.12 | Hydroxymethylglutaryl-CoA synthase, mitochondrial | HMGCS2 | A0A140VJL2 | 14.77 |
0.17 | Fatty acid-binding protein, liver | FABP1 | Q6FGL7 | 14.41 |
0.19 | 3-keto-steroid reductase | HSD17B7;hCG_2024989 | P56937-2 | 14.32 |
0.24 | Sulfate transporter | SLC26A2 | P50443 | 18.52 |
0.26 | Tumor necrosis factor alpha-induced protein 8-like protein 3 | TNFAIP8L3 | Q5GJ75 | 5.42 |
0.29 | Carbonic anhydrase 2 | HEL-76;CA2 | V9HW21 | 12.09 |
0.30 | Selenium-binding protein 1 | HEL-S-134P;SELENBP1 | V9HWG1 | 15.36 |
0.33 | cAMP-dependent protein kinase inhibitor beta | PKIB | Q5T0Z6 | 7.57 |
0.34 | Chloride anion exchanger | SLC26A3;DKFZp686P10213 | P40879 | 10.33 |
0.35 | UDP-glucuronosyltransferase 2A3 | UGT2A3 | Q6UWM9 | 14.95 |
0.36 | Chymotrypsin-C | CTRC | Q99895 | 5.37 |
0.36 | Hyaluronan and proteoglycan link protein 3 | HAPLN3 | A0A024RC58 | 8.55 |
0.37 | Calcium-activated chloride channel regulator 1 | CLCA1 | A8K7I4 | 6.68 |
0.37 | Tissue alpha-l-fucosidase | FUCA1 | P04066 | 10.42 |
0.37 | Phospholipase A(2) | PLA2G1B | F8W062 | 2.71 |
0.38 | UDP-glucuronosyltransferase 2B17 | UGT2B17;UGT2B15 | O75795 | 3.10 |
0.38 | Aquaporin-8 | AQP8 | Q53GF6 | 7.86 |
0.38 | Mimecan | OGN | Q7Z532 | 9.66 |
0.39 | Cadherin-17 | CDH17 | Q12864 | 17.16 |
0.39 | Alcohol dehydrogenase 1C | ADH1C | P00326 | 10.05 |