Fig. 2

Overview of protein identification/quantitation results and major acute phase protein levels in rhesus macaques infected with EBOV or Bp. a Number of proteins quantitated, and number of significant protein alterations in EBOV and Bp-infected plasma samples when compared to naïve NHP. b–d The relative protein abundances (y-axis) of b alpha-1 anti-trypsin member 3 (A1AT3), c C-reactive protein (CRP), and d serum amyloid A2 (SAA2) detected in plasma during EBOV or Bp infection are plotted versus post-infection day (x-axis). For all three proteins, similar maximum fold change increases were observed between the two infection types but different temporal kinetics contributed to higher levels observed at Day 3 and Day 6 PI for A1AT3, and Day 3 for CRP and SAA2 in the Bp-infected NHP. Abundance levels that were significantly different from levels found in naïve NHPs are designated with a black border around the symbol and levels that were significantly different between EBOV- and Bp-infected NHPs are designated with an asterisk (*). Statistical significance was based on 2-way ANOVA analysis