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Fig. 5 | Clinical Proteomics

Fig. 5

From: Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison

Fig. 5

Leucine-rich alpha-2 glycoprotein 1 (LRG1) and galectin-3 binding protein (G3BP) increase during EBOV infection in rhesus macaques. Neither protein was quantitated in naïve NHP plasma a Leucine-rich alpha-2 glycoprotein (LRG1) abundance levels increased to > 3 fold on Day 5 PI during EBOV infection whereas, Bp-infected NHPs exhibited a very slight increase. LRG1 levels were significantly higher in EBOV-infected animals on Days 5 and 6/7 PI (indicated with * symbol, based on 2-way ANOVA analysis). b G3BP abundance increased in EBOV-infected NHPs by > 2.5 fold on Day 6 PI, and was only quantitated in 1/5 Bp-infected animals. c Representative data from EBOV-infected NHP 1000 depicting Western blot confirmation of the FASP/TMT increased abundance of G3BP observed during EBOV infection. Equal volumes of plasma (5 μl) were loaded for each sample. No bands are visible in plasma from Bp-infected NHP JD27, confirming baseline levels and no increase during Bp infection. d FASP/TMT quantitation for G3BP for NHP 1000 (EBOV-infected: filled circle) and NHP JD27 (Bp-infected: filled square)

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