Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison

Ward, Michael D.; Brueggemann, Ernst E.; Kenny, Tara; Reitstetter, Raven E.; Mahone, Christopher R.; Trevino, Sylvia; Wetzel, Kelly; Donnelly, Ginger C.; Retterer, Cary; Norgren, Robert B.; Panchal, Rekha G.; Warren, Travis K.; Bavari, Sina; Cazares, Lisa H.

doi:10.1186/s12014-019-9227-3

Clinical Proteomics

Table 1 Proteins with > 2 fold abundance alteration with significant abundance change (a) in at least 4/10 EBOV infected NHP when compared to Naive NHP, (b) in at least 2/5 Bp infected

From: Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison

Accession	Description	# NHP quant.	Average CV %	Abundance ratio—Day PI					p Value versus naive—Day PI
Accession	Description	# NHP quant.	Average CV %	Day 2	Day 3	Day 4	Day 5	Day 6	Day 3	Day 4	Day 5	Day 6
P63261	Actin, cytoplasmic 2	8	5.9	0.97	0.99	1.06	1.63	4.41	Not quantitated in naive NHP plasma
ORM1_5004	Alpha-1 acid glycoprotein	10	13	1.03	1.27	2.55	3.91	4.82	NS	NS	0.0131	0.0025
SERPINA3_12	Alpha-1 antitrypsin, member 3	10	7.2	0.97	1.03	2.44	4.89	5.76	NS	0.0048	0.0003	0.0003
AHSG_197	Alpha-2-HS-glycoprotein	9	1.1	1.00	0.93	0.74	0.65	0.51	NS	NS	0.0061	0.0003
APOA4_337	Apolipoprotein A-IV	6	2.3	0.95	0.96	0.86	0.52	0.64	NS	NS	0.0058	0.1506
APOA1_335	Apolipoprotein A-I	10	0.58	0.95	0.93	0.81	0.65	0.51	NS	NS	NS	0.0003
P04114	Apolipoprotein B-100	7	0.59	1.10	1.05	0.97	1.24	2.16	NS	NS	0.0022	0.0003
APOE_348	Apolipoprotein E	10	0.70	0.96	0.98	1.10	1.66	2.50	NS	NS	0.0070	0.0003
CP_1356	Clusterin	10	0.62	0.98	0.96	0.96	1.18	1.98	NS	NS	0.0032	0.0003
CLU_1191	Complement C1R subcomponent	9	0.81	0.95	1.09	1.28	2.01	1.67	NS	NS	0.0018	0.0298
CRP_1401	C-reactive protein	8	23	1.02	1.07	3.68	7.55	6.99	Not quantitated in naive NHP plasma
HP_3240	Haptoglobin	10	4.6	1.07	1.20	1.71	2.31	2.13	NS	0.0484	0.0018	0.0023
HPX_3263	Hemopexin	10	3.1	1.02	1.08	1.40	2.08	2.47	NS	0.0538	0.0003	0.0003
LGALS3BP_3959	Galectin-3 binding protein	7	1.0	1.04	0.84	1.11	1.47	2.57	Not quantitated in naive NHP plasma
LRG1_116844	Leucine-rich alpha-2-glycoprotein 1	7	13	1.04	1.12	2.20	3.88	3.40	Not quantitated in naive NHP plasma
LBP_3929	Lipopolysaccharide binding protein	7	19	0.83	0.97	1.45	2.04	2.41	Not quantitated in naive NHP plasma
P05109	S100 calcium binding protein A8	8	0.74	0.88	1.02	1.19	1.96	4.95	Not quantitated in naive NHP plasma
S100A9_6280	S100 calcium binding protein A9	4	18	1.00	1.04	1.13	2.57	8.43	Not quantitated in naive NHP plasma
SAA2_6289	Serum amyloid A2	9	16	0.88	0.91	2.44	4.29	4.50	Not quantitated in naive NHP plasma

Accession	Description	# NHP quant.	Average CV %	Abundance ratio—Day PI					p Value versus naive—Day PI
Accession	Description	# NHP quant.	Average CV %	Day 1	Day 3	Day 5	Day 7	Day 9	Day 3	Day 5	Day 7	Day 9
APOA2_336	Apolipoprotein A-II	4	2.7	0.86	0.66	0.51	0.44	0.39	0.0345	NS	0.0131	0.0003
ORM1_5004	Alpha-1 acid glycoprotein	5	30	1.13	2.49	2.96	3.53	3.53	NS	0.0222	0.0030	0.0046
SERPINA3_12	Alpha-1 antitrypsin, member 3	5	30	1.01	2.73	3.01	3.14	3.21	0.0191	0.0121	0.0046	0.0244
P0C0L5	Complement C4-B	5	12	1.72	1.80	1.92	1.98	2.11	Not quantitated in naive NHP plasma
CRP_1401	C-reactive protein	3	> 100%	0.91	10.98	11.20	10.87	6.99	Not quantitated in naive NHP plasma
FGA_2243	Fibrinogen alpha chain	5	13	1.13	2.30	2.38	2.27	2.22	0.0018	0.0018	0.0020	0.0056
FGB_2244	Fibrinogen beta chain	5	8.0	1.06	1.85	2.09	1.90	1.95	0.0013	0.0003	0.0003	0.0007
HP_3240	Haptoglobin	5	10	1.02	2.33	2.81	3.13	3.04	0.0189	0.0023	0.0023	0.0043
ITIH1_3697	Inter-alpha-trypsin inhibitor HC 1	4	6.0	0.74	0.60	0.51	0.44	0.40	0.0054	0.0018	0.0005	0.0007
LBP_3929	Lipopolysaccharide binding protein	4	33	1.07	2.12	2.25	2.17	2.01	Not quantitated in naive NHP plasma
LUM_4060	Lumican	4	6.2	1.30	0.58	0.30	0.31	0.27	NS	0.0284	0.0148	NS
P06702	S100 calcium binding protein A9	2	14	1.14	2.08	2.90	4.36	5.85	Not quantitated in naive NHP plasma
SAA2-SAA4_100528017	SAA2-SAA4 readthrough	5	7.7	1.55	3.46	2.77	1.99	2.19	Not quantitated in naive NHP plasma
SAA2_6289	Serum amyloid A2	5	55	1.71	8.56	7.20	5.56	4.98	Not quantitated in naive NHP plasma

NS not significant

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