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Table 1 Proteins with > 2 fold abundance alteration with significant abundance change (a) in at least 4/10 EBOV infected NHP when compared to Naive NHP, (b) in at least 2/5 Bp infected

From: Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison

Accession Description # NHP quant. Average CV % Abundance ratio—Day PI p Value versus naive—Day PI
Day 2 Day 3 Day 4 Day 5 Day 6 Day 3 Day 4 Day 5 Day 6
P63261 Actin, cytoplasmic 2 8 5.9 0.97 0.99 1.06 1.63 4.41 Not quantitated in naive NHP plasma
ORM1_5004 Alpha-1 acid glycoprotein 10 13 1.03 1.27 2.55 3.91 4.82 NS NS 0.0131 0.0025
SERPINA3_12 Alpha-1 antitrypsin, member 3 10 7.2 0.97 1.03 2.44 4.89 5.76 NS 0.0048 0.0003 0.0003
AHSG_197 Alpha-2-HS-glycoprotein 9 1.1 1.00 0.93 0.74 0.65 0.51 NS NS 0.0061 0.0003
APOA4_337 Apolipoprotein A-IV 6 2.3 0.95 0.96 0.86 0.52 0.64 NS NS 0.0058 0.1506
APOA1_335 Apolipoprotein A-I 10 0.58 0.95 0.93 0.81 0.65 0.51 NS NS NS 0.0003
P04114 Apolipoprotein B-100 7 0.59 1.10 1.05 0.97 1.24 2.16 NS NS 0.0022 0.0003
APOE_348 Apolipoprotein E 10 0.70 0.96 0.98 1.10 1.66 2.50 NS NS 0.0070 0.0003
CP_1356 Clusterin 10 0.62 0.98 0.96 0.96 1.18 1.98 NS NS 0.0032 0.0003
CLU_1191 Complement C1R subcomponent 9 0.81 0.95 1.09 1.28 2.01 1.67 NS NS 0.0018 0.0298
CRP_1401 C-reactive protein 8 23 1.02 1.07 3.68 7.55 6.99 Not quantitated in naive NHP plasma
HP_3240 Haptoglobin 10 4.6 1.07 1.20 1.71 2.31 2.13 NS 0.0484 0.0018 0.0023
HPX_3263 Hemopexin 10 3.1 1.02 1.08 1.40 2.08 2.47 NS 0.0538 0.0003 0.0003
LGALS3BP_3959 Galectin-3 binding protein 7 1.0 1.04 0.84 1.11 1.47 2.57 Not quantitated in naive NHP plasma
LRG1_116844 Leucine-rich alpha-2-glycoprotein 1 7 13 1.04 1.12 2.20 3.88 3.40 Not quantitated in naive NHP plasma
LBP_3929 Lipopolysaccharide binding protein 7 19 0.83 0.97 1.45 2.04 2.41 Not quantitated in naive NHP plasma
P05109 S100 calcium binding protein A8 8 0.74 0.88 1.02 1.19 1.96 4.95 Not quantitated in naive NHP plasma
S100A9_6280 S100 calcium binding protein A9 4 18 1.00 1.04 1.13 2.57 8.43 Not quantitated in naive NHP plasma
SAA2_6289 Serum amyloid A2 9 16 0.88 0.91 2.44 4.29 4.50 Not quantitated in naive NHP plasma
Accession Description # NHP quant. Average CV % Abundance ratio—Day PI p Value versus naive—Day PI
Day 1 Day 3 Day 5 Day 7 Day 9 Day 3 Day 5 Day 7 Day 9
APOA2_336 Apolipoprotein A-II 4 2.7 0.86 0.66 0.51 0.44 0.39 0.0345 NS 0.0131 0.0003
ORM1_5004 Alpha-1 acid glycoprotein 5 30 1.13 2.49 2.96 3.53 3.53 NS 0.0222 0.0030 0.0046
SERPINA3_12 Alpha-1 antitrypsin, member 3 5 30 1.01 2.73 3.01 3.14 3.21 0.0191 0.0121 0.0046 0.0244
P0C0L5 Complement C4-B 5 12 1.72 1.80 1.92 1.98 2.11 Not quantitated in naive NHP plasma
CRP_1401 C-reactive protein 3 > 100% 0.91 10.98 11.20 10.87 6.99 Not quantitated in naive NHP plasma
FGA_2243 Fibrinogen alpha chain 5 13 1.13 2.30 2.38 2.27 2.22 0.0018 0.0018 0.0020 0.0056
FGB_2244 Fibrinogen beta chain 5 8.0 1.06 1.85 2.09 1.90 1.95 0.0013 0.0003 0.0003 0.0007
HP_3240 Haptoglobin 5 10 1.02 2.33 2.81 3.13 3.04 0.0189 0.0023 0.0023 0.0043
ITIH1_3697 Inter-alpha-trypsin inhibitor HC 1 4 6.0 0.74 0.60 0.51 0.44 0.40 0.0054 0.0018 0.0005 0.0007
LBP_3929 Lipopolysaccharide binding protein 4 33 1.07 2.12 2.25 2.17 2.01 Not quantitated in naive NHP plasma
LUM_4060 Lumican 4 6.2 1.30 0.58 0.30 0.31 0.27 NS 0.0284 0.0148 NS
P06702 S100 calcium binding protein A9 2 14 1.14 2.08 2.90 4.36 5.85 Not quantitated in naive NHP plasma
SAA2-SAA4_100528017 SAA2-SAA4 readthrough 5 7.7 1.55 3.46 2.77 1.99 2.19 Not quantitated in naive NHP plasma
SAA2_6289 Serum amyloid A2 5 55 1.71 8.56 7.20 5.56 4.98 Not quantitated in naive NHP plasma
  1. NS not significant