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Table 2 Proteins with < 2 fold alteration with significant abundance change in (a) at least 4/10 EBOV infected NHP when compared to naive NHP, (b) at least 2/5 Bp infected NHP when compared to naive NHP

From: Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison

Accession Description # NHP quant. Average CV % Abundance ratio—Day PI p Value versus naive—Day PI
Day 2 Day 3 Day 4 Day 5 Day 6 Day 4 Day 5 Day 6
AFM_173 Afamin 9 1 1.00 1.02 1.00 0.83 0.79 0.0406 0.0005 0.0002
ALB_213 Albumin 10 0.73 1.01 1.10 0.92 0.76 0.67 0.0441 0.0002 0.0002
SERPINA1_5265 Alpha-1 antitrypsin member 1 10 0.61 0.99 1.03 1.12 1.30 1.37 NS 0.0002 0.0002
APOA2_336 Apolipoprotein A-II 7 2.1 1.09 0.90 0.77 0.59 0.55 0.0065 0.0011 0.0002
APOB_338 Apolipoprotein B48 10 1.8 1.02 0.94 0.94 1.15 1.61 NS 0.0091 0.0002
APOC3_345 Apolipoprotein C-III 6 3 0.99 0.92 0.63 0.67 0.77 0.0132 0.0024 0.0033
APOH_350 Apolipoprotein H 6 1.6 1.03 1.03 0.82 0.60 0.59 0.0020 0.0002 0.0002
SERPING1_710 C1 inhibitor member 1 10 0.34 0.98 0.98 1.06 1.14 1.37 NS 0.0106 0.0002
CPN2_1370 Carboxypeptidase N subunit 2 6 1.3 0.95 1.04 1.01 1.11 1.43 NS NS 0.0012
CP_1356 Ceruloplasmin (ferroxidase) 10 1 1.00 1.04 1.14 1.29 1.42 NS 0.0436 0.0023
C1S_716 Complement C1S subcomponent 6 1.3 0.97 1.01 1.20 1.48 1.69 NS NS 0.0133
C2_717 Complement component 2 6 1.1 0.98 0.97 1.01 1.17 1.60 NS NS 0.0135
C9_735 Complement component 9 10 1.2 1.06 1.02 1.15 1.44 1.58 0.0106 0.0007 0.0004
CFB_629 Complement factor B 10 1.8 1.03 1.07 1.28 1.55 1.90 0.0095 0.0002 0.0002
FGA_2243 Fibrinogen alpha chain 10 0.64 1.00 1.02 1.26 1.38 1.10 0.0413 0.0183 NS
FGB_2244 Fibrinogen beta chain 10 0.5 0.97 1.03 1.22 1.46 1.07 NS 0.0051 NS
FGG_2266 Fibrinogen gamma chain 10 0.62 1.04 1.02 1.22 1.39 1.17 0.0295 0.0031 NS
FN1_2335 Fibronectin 1 10 1.1 0.99 0.93 0.75 0.74 0.78 0.0023 0.0033 0.0095
FETUB_26998 Fetuin B 8 1.8 0.91 0.97 0.83 0.62 0.60 NS 0.0195 0.0320
HRG_3273 Histidine rich glycoprotein 10 0.71 0.97 0.96 0.84 0.71 0.60 0.0514 0.0050 0.0003
ITIH1_3697 Inter-alpha-trypsin inhibitor HC 1 10 0.44 0.98 0.91 0.87 0.80 0.68 0.0022 0.0002 0.0002
ITIH2_3698 Inter-alpha-trypsin inhibitor HC 2 10 0.8 0.98 0.97 0.96 0.73 0.64 0.0307 0.0013 0.0002
ITIH3_3699 Inter-alpha-trypsin inhibitor HC 3 10 0.53 0.99 1.02 1.03 1.18 1.40 NS 0.0062 0.0004
ITIH4_3700 Inter-alpha-trypsin inhibitor HC4 10 1.2 1.00 1.01 1.10 1.21 1.36 NS NS 0.0037
KNG1_3827 Kininogen 1 6 2 0.98 1.03 0.85 0.63 0.52 NS 0.0078 0.0005
LUM_4060 Lumican 8 1.3 1.02 0.96 0.71 0.60 0.68 NS 0.0418 0.0066
PLG_5340 Plasminogen 10 1 0.95 1.00 0.91 0.74 0.67 NS 0.0008 0.0003
TF_7018 Transferrin 10 0.61 0.99 1.00 0.95 0.82 0.70 0.0389 0.0002 0.0002
TTR_7276 Transthyretin 10 0.6 0.95 0.88 0.82 0.74 0.80 0.0498 0.0128 0.0497
GC_2638 Vitamin D binding protein 10 0.84 1.03 1.03 0.97 0.82 0.77 NS 0.0033 0.0007
Accession Description # NHP quant. Average CV % Abundance ratio—Day PI p Value versus naive—Day PI
Day 1 Day 3 Day 5 Day 7 Day 9 Day 3 Day 5 Day 7 Day 9
AFM_173 Afamin 5 3.5 1.10 0.85 0.82 0.69 0.77 0.0209 0.0051 0.0006 0.0007
ALB_213 Albumin 5 3.3 0.96 0.77 0.63 0.61 0.57 0.0307 0.0025 0.0009 0.0025
SERPINA1_5265 Alpha-1 antitrypsin member 1 5 7.5 1.19 1.49 1.86 1.77 1.89 0.0297 0.0071 0.0025 0.0058
APOA1_335 Apolipoprotein A-I 5 3.2 1.13 0.81 0.59 0.54 0.55 NS 0.0229 0.0101 0.0095
APOH_350 Apolipoprotein H 5 8.2 0.86 0.63 0.62 0.65 0.69 0.0002 0.0002 0.0002 0.0002
CPN2_1370 Carboxypeptidase N subunit 2 3 3.4 1.20 1.33 1.57 1.56 1.59 0.0011 0.0006 0.0002 0.0002
CP_1356 Ceruloplasmin (ferroxidase) 5 4.8 1.05 1.32 1.62 1.59 1.73 0.0354 0.0025 0.0018 0.0023
C3_718 Complement component 3 5 2.9 1.03 1.22 1.29 1.37 1.30 NS 0.0068 0.0008 0.0038
C4A_720 Complement component 4A 5 4.6 1.22 1.31 1.52 1.35 1.22 0.0307 0.0022 0.0094 NS
C5_727 Complement component 5 5 3.0 1.27 1.14 1.36 1.33 1.46 NS 0.0043 0.0068 0.0009
C9_735 Complement component 9 5 5.3 1.06 1.36 1.57 1.62 1.61 NS 0.0033 0.0004 0.0024
CFB_629 Complement factor B 5 4.8 0.97 1.26 1.30 1.35 1.26 0.0155 0.0015 0.0125 0.0498
FGG_2266 Fibrinogen gamma chain 5 3.3 0.90 1.60 1.79 1.88 1.88 0.0005 0.0002 0.0002 0.0010
FN1_2335 Fibronectin 1 5 5.1 0.99 0.71 0.78 0.78 0.78 0.0002 0.0002 0.0012 NS
HPX_3263 Hemopexin 5 7.9 0.96 1.44 1.55 1.79 1.53 0.0118 0.0029 0.0039 0.0420
HRG_3273 Histidine rich glycoprotein 5 5.3 1.01 0.80 0.60 0.56 0.56 0.0418 0.0002 0.0002 0.0002
ITIH2_3698 Inter-alpha-trypsin inhibitor HC 2 4 3.3 0.95 0.71 0.68 0.66 0.62 0.0183 0.0013 0.0004 0.0005
ITIH3_3699 Inter-alpha-trypsin inhibitor HC 3 5 7.3 1.08 1.25 1.51 1.47 1.59 0.0227 0.0093 0.0094 0.0070
ITIH4_3700 Inter-alpha-trypsin inhibitor HC 4 5 4.8 1.07 1.25 1.58 1.49 1.41 NS 0.0010 0.0004 0.0031
LRG1_116844 Leucine-rich alpha-2-glycoprotein 1 4 7.7 1.09 1.73 1.75 1.63 1.54 Not quantitated in naive NHP plasma
TF_7018 Transferrin 5 2.5 1.02 0.90 0.85 0.86 0.84 NS 0.0035 0.0219 0.0141
  1. NS not significant
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Clinical Proteomics

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