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Table 2 Proteins with < 2 fold alteration with significant abundance change in (a) at least 4/10 EBOV infected NHP when compared to naive NHP, (b) at least 2/5 Bp infected NHP when compared to naive NHP

From: Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison

Accession

Description

# NHP quant.

Average CV %

Abundance ratio—Day PI

p Value versus naive—Day PI

Day 2

Day 3

Day 4

Day 5

Day 6

Day 4

Day 5

Day 6

AFM_173

Afamin

9

1

1.00

1.02

1.00

0.83

0.79

0.0406

0.0005

0.0002

ALB_213

Albumin

10

0.73

1.01

1.10

0.92

0.76

0.67

0.0441

0.0002

0.0002

SERPINA1_5265

Alpha-1 antitrypsin member 1

10

0.61

0.99

1.03

1.12

1.30

1.37

NS

0.0002

0.0002

APOA2_336

Apolipoprotein A-II

7

2.1

1.09

0.90

0.77

0.59

0.55

0.0065

0.0011

0.0002

APOB_338

Apolipoprotein B48

10

1.8

1.02

0.94

0.94

1.15

1.61

NS

0.0091

0.0002

APOC3_345

Apolipoprotein C-III

6

3

0.99

0.92

0.63

0.67

0.77

0.0132

0.0024

0.0033

APOH_350

Apolipoprotein H

6

1.6

1.03

1.03

0.82

0.60

0.59

0.0020

0.0002

0.0002

SERPING1_710

C1 inhibitor member 1

10

0.34

0.98

0.98

1.06

1.14

1.37

NS

0.0106

0.0002

CPN2_1370

Carboxypeptidase N subunit 2

6

1.3

0.95

1.04

1.01

1.11

1.43

NS

NS

0.0012

CP_1356

Ceruloplasmin (ferroxidase)

10

1

1.00

1.04

1.14

1.29

1.42

NS

0.0436

0.0023

C1S_716

Complement C1S subcomponent

6

1.3

0.97

1.01

1.20

1.48

1.69

NS

NS

0.0133

C2_717

Complement component 2

6

1.1

0.98

0.97

1.01

1.17

1.60

NS

NS

0.0135

C9_735

Complement component 9

10

1.2

1.06

1.02

1.15

1.44

1.58

0.0106

0.0007

0.0004

CFB_629

Complement factor B

10

1.8

1.03

1.07

1.28

1.55

1.90

0.0095

0.0002

0.0002

FGA_2243

Fibrinogen alpha chain

10

0.64

1.00

1.02

1.26

1.38

1.10

0.0413

0.0183

NS

FGB_2244

Fibrinogen beta chain

10

0.5

0.97

1.03

1.22

1.46

1.07

NS

0.0051

NS

FGG_2266

Fibrinogen gamma chain

10

0.62

1.04

1.02

1.22

1.39

1.17

0.0295

0.0031

NS

FN1_2335

Fibronectin 1

10

1.1

0.99

0.93

0.75

0.74

0.78

0.0023

0.0033

0.0095

FETUB_26998

Fetuin B

8

1.8

0.91

0.97

0.83

0.62

0.60

NS

0.0195

0.0320

HRG_3273

Histidine rich glycoprotein

10

0.71

0.97

0.96

0.84

0.71

0.60

0.0514

0.0050

0.0003

ITIH1_3697

Inter-alpha-trypsin inhibitor HC 1

10

0.44

0.98

0.91

0.87

0.80

0.68

0.0022

0.0002

0.0002

ITIH2_3698

Inter-alpha-trypsin inhibitor HC 2

10

0.8

0.98

0.97

0.96

0.73

0.64

0.0307

0.0013

0.0002

ITIH3_3699

Inter-alpha-trypsin inhibitor HC 3

10

0.53

0.99

1.02

1.03

1.18

1.40

NS

0.0062

0.0004

ITIH4_3700

Inter-alpha-trypsin inhibitor HC4

10

1.2

1.00

1.01

1.10

1.21

1.36

NS

NS

0.0037

KNG1_3827

Kininogen 1

6

2

0.98

1.03

0.85

0.63

0.52

NS

0.0078

0.0005

LUM_4060

Lumican

8

1.3

1.02

0.96

0.71

0.60

0.68

NS

0.0418

0.0066

PLG_5340

Plasminogen

10

1

0.95

1.00

0.91

0.74

0.67

NS

0.0008

0.0003

TF_7018

Transferrin

10

0.61

0.99

1.00

0.95

0.82

0.70

0.0389

0.0002

0.0002

TTR_7276

Transthyretin

10

0.6

0.95

0.88

0.82

0.74

0.80

0.0498

0.0128

0.0497

GC_2638

Vitamin D binding protein

10

0.84

1.03

1.03

0.97

0.82

0.77

NS

0.0033

0.0007

Accession

Description

# NHP quant.

Average CV %

Abundance ratio—Day PI

p Value versus naive—Day PI

Day 1

Day 3

Day 5

Day 7

Day 9

Day 3

Day 5

Day 7

Day 9

AFM_173

Afamin

5

3.5

1.10

0.85

0.82

0.69

0.77

0.0209

0.0051

0.0006

0.0007

ALB_213

Albumin

5

3.3

0.96

0.77

0.63

0.61

0.57

0.0307

0.0025

0.0009

0.0025

SERPINA1_5265

Alpha-1 antitrypsin member 1

5

7.5

1.19

1.49

1.86

1.77

1.89

0.0297

0.0071

0.0025

0.0058

APOA1_335

Apolipoprotein A-I

5

3.2

1.13

0.81

0.59

0.54

0.55

NS

0.0229

0.0101

0.0095

APOH_350

Apolipoprotein H

5

8.2

0.86

0.63

0.62

0.65

0.69

0.0002

0.0002

0.0002

0.0002

CPN2_1370

Carboxypeptidase N subunit 2

3

3.4

1.20

1.33

1.57

1.56

1.59

0.0011

0.0006

0.0002

0.0002

CP_1356

Ceruloplasmin (ferroxidase)

5

4.8

1.05

1.32

1.62

1.59

1.73

0.0354

0.0025

0.0018

0.0023

C3_718

Complement component 3

5

2.9

1.03

1.22

1.29

1.37

1.30

NS

0.0068

0.0008

0.0038

C4A_720

Complement component 4A

5

4.6

1.22

1.31

1.52

1.35

1.22

0.0307

0.0022

0.0094

NS

C5_727

Complement component 5

5

3.0

1.27

1.14

1.36

1.33

1.46

NS

0.0043

0.0068

0.0009

C9_735

Complement component 9

5

5.3

1.06

1.36

1.57

1.62

1.61

NS

0.0033

0.0004

0.0024

CFB_629

Complement factor B

5

4.8

0.97

1.26

1.30

1.35

1.26

0.0155

0.0015

0.0125

0.0498

FGG_2266

Fibrinogen gamma chain

5

3.3

0.90

1.60

1.79

1.88

1.88

0.0005

0.0002

0.0002

0.0010

FN1_2335

Fibronectin 1

5

5.1

0.99

0.71

0.78

0.78

0.78

0.0002

0.0002

0.0012

NS

HPX_3263

Hemopexin

5

7.9

0.96

1.44

1.55

1.79

1.53

0.0118

0.0029

0.0039

0.0420

HRG_3273

Histidine rich glycoprotein

5

5.3

1.01

0.80

0.60

0.56

0.56

0.0418

0.0002

0.0002

0.0002

ITIH2_3698

Inter-alpha-trypsin inhibitor HC 2

4

3.3

0.95

0.71

0.68

0.66

0.62

0.0183

0.0013

0.0004

0.0005

ITIH3_3699

Inter-alpha-trypsin inhibitor HC 3

5

7.3

1.08

1.25

1.51

1.47

1.59

0.0227

0.0093

0.0094

0.0070

ITIH4_3700

Inter-alpha-trypsin inhibitor HC 4

5

4.8

1.07

1.25

1.58

1.49

1.41

NS

0.0010

0.0004

0.0031

LRG1_116844

Leucine-rich alpha-2-glycoprotein 1

4

7.7

1.09

1.73

1.75

1.63

1.54

Not quantitated in naive NHP plasma

TF_7018

Transferrin

5

2.5

1.02

0.90

0.85

0.86

0.84

NS

0.0035

0.0219

0.0141

  1. NS not significant