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Table 1 The efficiency of depletion of the most abundant 14 plasma proteins by the MARS 14 immunodepletion and ProteoMiner

From: Affinity depletion versus relative protein enrichment: a side-by-side comparison of two major strategies for increasing human cerebrospinal fluid proteome coverage

    MARS 14 ProteoMiner
%Removed %Removed
P02768 Serum albumin ALB 97.4 71.9
P02647 Apolipoprotein A-I APOA1 99.9 < 33
P02652 Apolipoprotein A-II APOA2 75.6 < 33
P01876 Ig alpha-1 chain C region IGHA1 99.9 97.8
P01023 Alpha-2-macroglobulin A2M 99.9 68.4
P02763 Alpha-1-acid glycoprotein 1 ORM1 99.7 97.8
P01009 Alpha-1-antitrypsin SERPINA1 99.7 84.3
P01857 Ig gamma-1 chain C region IGHG1 99.6 70.9
P02787 Serotransferrin TF 99.4 96.1
P00738 Haptoglobin HP 98.7 92.1
P01024 Complement C3 C3 98.1 <33
P02766 Transthyretin TTR 95.2 89.0
P02675 Fibrinogen beta chain FGB 94.5 < 33
P02671 Fibrinogen alpha chain FGA 93.7 < 33
P02679 Fibrinogen gamma chain FGG 91.7 < 33
P01871 IgM IGHM 100a < 33
  1. Data from label-free quantification based on MS1 peptide signal intensities
  2. aIgM was not detected in the CSF after MARS 14 immunodepletion