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Table 1 The efficiency of depletion of the most abundant 14 plasma proteins by the MARS 14 immunodepletion and ProteoMiner

From: Affinity depletion versus relative protein enrichment: a side-by-side comparison of two major strategies for increasing human cerebrospinal fluid proteome coverage

   

MARS 14

ProteoMiner

%Removed

%Removed

P02768

Serum albumin

ALB

97.4

71.9

P02647

Apolipoprotein A-I

APOA1

99.9

< 33

P02652

Apolipoprotein A-II

APOA2

75.6

< 33

P01876

Ig alpha-1 chain C region

IGHA1

99.9

97.8

P01023

Alpha-2-macroglobulin

A2M

99.9

68.4

P02763

Alpha-1-acid glycoprotein 1

ORM1

99.7

97.8

P01009

Alpha-1-antitrypsin

SERPINA1

99.7

84.3

P01857

Ig gamma-1 chain C region

IGHG1

99.6

70.9

P02787

Serotransferrin

TF

99.4

96.1

P00738

Haptoglobin

HP

98.7

92.1

P01024

Complement C3

C3

98.1

<33

P02766

Transthyretin

TTR

95.2

89.0

P02675

Fibrinogen beta chain

FGB

94.5

< 33

P02671

Fibrinogen alpha chain

FGA

93.7

< 33

P02679

Fibrinogen gamma chain

FGG

91.7

< 33

P01871

IgM

IGHM

100a

< 33

  1. Data from label-free quantification based on MS1 peptide signal intensities
  2. aIgM was not detected in the CSF after MARS 14 immunodepletion