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Table 3 Hazards ratio (HR) for incident CVD (n = 224, 13.1%) in 1705 never smokers, expressed per 1 SD increment of protein biomarkers

From: Biomarkers of blood cadmium and incidence of cardiovascular events in non-smokers: results from a population-based proteomics study

Protein

Model 1a

P

Model 2b

P

KIM-1

1.29 (1.12–1.48)

< 0.001

1.16 (1.01–1.34)

0.033

FGF23

1.18 (1.03–1.36)

0.015

1.10 (0.96–1.27)

0.177

MMP12

1.29 (1.12–1.49)

< 0.001

1.23 (1.06–1.43)

0.006

CTSL1

1.28 (1.11–1.47)

0.001

1.22 (1.05–1.41)

0.007

TNFR2

1.25 (1.09–1.44)

0.001

1.16 (1.01–1.34)

0.036

UPAR

1.32 (1.14–1.54)

< 0.001

1.26 (1.08–1.47)

0.003

CCL3

1.15 (1.01–1.30)

0.037

1.06 (0.92–1.22)

0.441

CX3CL1

1.14 (1.01–1.30)

0.046

1.17 (1.02–1.33)

0.021

  1. aModel 1: adjusted for age and sex. Hazard ratios (95% confidence interval) in all models
  2. bModel 2: adjusted for age, sex, diabetes, systolic blood pressure, HDL, LDL, use of blood pressure, use of lipid-lowering drugs, and waist circumference