Identification of prothymosin alpha (PTMA) as a biomarker for esophageal squamous cell carcinoma (ESCC) by label-free quantitative proteomics and Quantitative Dot Blot (QDB)

Zhu, Yanping; Qi, Xiaoying; Yu, Cuicui; Yu, Shoujun; Zhang, Chao; Zhang, Yuan; Liu, Xiuxiu; Xu, Yuxue; Yang, Chunhua; Jiang, Wenguo; Tian, Geng; Li, Xuri; Bergquist, Jonas; Zhang, Jiandi; Wang, Lei; Mi, Jia

doi:10.1186/s12014-019-9232-6

Clinical Proteomics

Table 3 List of 155 proteins that were overexpressed in ESCC tissues

From: Identification of prothymosin alpha (PTMA) as a biomarker for esophageal squamous cell carcinoma (ESCC) by label-free quantitative proteomics and Quantitative Dot Blot (QDB)

IDs	Log ratio	P value	Protein names
P60842	7.814	0.000	Eukaryotic initiation factor 4A-I
P23396	6.277	0.000	40S ribosomal protein S3
P52272	7.623	0.000	Heterogeneous nuclear ribonucleoprotein M
P43686	10.195	0.000	26S protease regulatory subunit 6B
P14866	8.871	0.000	Heterogeneous nuclear ribonucleoprotein L
P53675	5.484	0.001	Clathrin heavy chain;Clathrin heavy chain 1
P84090	11.171	0.001	Enhancer of rudimentary homolog
P22392	12.881	0.001	Nucleoside diphosphate kinase
Q01105	7.330	0.001	Protein SET;Protein SETSIP
P84103	7.084	0.001	Serine/arginine-rich splicing factor 3
P07900	9.462	0.001	Heat shock protein HSP 90-alpha
Q01518	2.076	0.001	Adenylyl cyclase-associated protein
Q15233	22.489	0.001	Non-POU domain-containing octamer-binding protein
P51149	7.249	0.001	Ras-related protein Rab-7a
Q05CK9	9.797	0.001	Heterogeneous nuclear ribonucleoprotein Q
P10809	9.235	0.001	60 kDa heat shock protein, mitochondrial
P68371	1.935	0.001	Tubulin beta-4B chain
P37802	3.333	0.001	Transgelin-2
P62826	6.962	0.002	GTP-binding nuclear protein Ran
P25398	4.816	0.002	40S ribosomal protein S12
P57723	4.611	0.002	Poly(rC)-binding protein 1
Q12906	28.577	0.002	Interleukin enhancer-binding factor 3
P08865	5.309	0.002	40S ribosomal protein SA
P63244	6.237	0.002	Guanine nucleotide-binding protein subunit beta-2-like 1
P14314	14.510	0.002	Glucosidase 2 subunit beta
P60900	9.105	0.002	Proteasome subunit alpha type
P06748	12.711	0.002	Nucleophosmin
P05388	8.012	0.002	60S acidic ribosomal protein P0
P46940	3.595	0.003	Ras GTPase-activating-like protein IQGAP1
P61978	10.444	0.003	Heterogeneous nuclear ribonucleoprotein K
P05141	2.807	0.003	ADP/ATP translocase 2
Q6LDX7	13.007	0.003	Tyrosine-protein kinase receptor
Q99623	14.381	0.003	Prohibitin-2
P06733	2.361	0.003	Alpha-enolase
P13639	5.459	0.003	Elongation factor 2
Q15084	43.388	0.003	Protein disulfide-isomerase A6
Q96DV6	3.944	0.003	40S ribosomal protein S6
Q66K53	9.606	0.003	HNRPA3 protein
P15880	4.502	0.003	40S ribosomal protein S2
P39019	5.898	0.004	40S ribosomal protein S19
P63104	2.043	0.004	14-3-3 protein zeta/delta
P22626	6.638	0.004	Heterogeneous nuclear ribonucleoproteins A2/B1
P30101	6.086	0.005	Protein disulfide-isomerase
P25786	8.420	0.005	Proteasome subunit alpha type-1
P11940	12.404	0.006	Polyadenylate-binding protein
P16401	4.877	0.006	Histone H1.5
P07237	5.704	0.006	Protein disulfide-isomerase
Q16777	10.160	0.006	Histone H2A type 2-C;Histone H2A type 2-A
P05386	5.889	0.006	60S acidic ribosomal protein P1
P31948	11.491	0.006	Stress-induced-phosphoprotein 1
P31946	2.156	0.007	14-3-3 protein beta/alpha
P68104	2.558	0.007	Elongation factor 1-alpha
P00338	1.590	0.007	L-lactate dehydrogenase
Q14103	6.189	0.007	Heterogeneous nuclear ribonucleoprotein D0
P38646	10.649	0.007	Stress-70 protein, mitochondrial
P26641	19.766	0.007	Elongation factor 1-gamma
O75347	4.168	0.008	Tubulin-specific chaperone A
P09429	5.878	0.008	High mobility group protein B1
P62942	7.427	0.008	Peptidyl-prolyl cis–trans isomerase FKBP1A
Q9NUV1	7.289	0.008	Cytosolic non-specific dipeptidase
P11021	7.467	0.008	78 kDa glucose-regulated protein
P11142	2.320	0.008	Heat shock cognate 71 kDa protein
P02533	5.320	0.008	Keratin, type I cytoskeletal 14
P30040	6.657	0.008	Endoplasmic reticulum resident protein 29
P50990	11.713	0.008	T-complex protein 1 subunit theta
P46783	9.508	0.008	40S ribosomal protein S10
P31943	14.091	0.008	Heterogeneous nuclear ribonucleoprotein H
P19338	13.679	0.009	Nucleolin
P14625	13.173	0.009	Endoplasmin
Q92597	4.464	0.009	Protein NDRG1
P26599	19.501	0.009	Polypyrimidine tract-binding protein 1
P68363	2.317	0.009	Tubulin alpha-1B chain
P61604	9.723	0.009	10 kDa heat shock protein, mitochondrial
P08238	8.920	0.009	Heat shock protein HSP 90-beta
Q00839	15.338	0.009	Heterogeneous nuclear ribonucleoprotein U
P04843	64.275	0.009	Dolichyl-diphosphooligosaccharide–protein glycosyltransferase subunit 1
P09651	10.489	0.010	Heterogeneous nuclear ribonucleoprotein A1
P22314	3.758	0.010	Ubiquitin-like modifier-activating enzyme 1
P30085	3.180	0.010	UMP-CMP kinase
P23246	39.026	0.011	Splicing factor, proline- and glutamine-rich
P29692	13.726	0.011	Elongation factor 1-delta
P27797	7.508	0.011	Calreticulin
Q06830	1.788	0.011	Peroxiredoxin-1
P84243	2.541	0.012	Histone H3
P05023	15.342	0.012	Sodium/potassium-transporting ATPase subunit alpha-1
Q14974	3.995	0.014	Importin subunit beta-1
P30154	2.882	0.014	Serine/threonine-protein phosphatase 2A
P49448	5.013	0.015	Glutamate dehydrogenase
P20700	14.379	0.015	Lamin-B1
P55072	6.054	0.016	Transitional endoplasmic reticulum ATPase
P35579	8.278	0.016	Myosin-9
P40227	8.241	0.016	T-complex protein 1 subunit zeta
P13010	223.628	0.017	X-ray repair cross-complementing protein 5
Q03252	12.919	0.017	Lamin-B2
P27824	9.105	0.017	Calnexin
P02545	1.376	0.017	Prelamin-A/C;Lamin-A/C
P67936	10.102	0.017	Tropomyosin alpha-4 chain
P04908	2.018	0.018	Histone H2A
P13797	5.684	0.019	Plastin-3
P52907	3.377	0.019	F-actin-capping protein subunit alpha-1
P63241	4.197	0.019	Eukaryotic translation initiation factor 5A
P62491	3.628	0.019	Ras-related protein Rab-11A;Ras-related protein Rab-11B
P45880	2.304	0.020	Voltage-dependent anion-selective channel protein 2
P05387	4.257	0.020	60S acidic ribosomal protein P2
Q5SRT3	3.484	0.021	Chloride intracellular channel protein
P07437	3.687	0.021	Tubulin beta chain
P23284	8.401	0.022	Peptidyl-prolyl cis–trans isomerase
P18124	5.442	0.022	60S ribosomal protein L7
P07355	1.909	0.022	Annexin;Annexin A2
P46777	12.124	0.023	60S ribosomal protein L5
Q99714	1.923	0.023	3-hydroxyacyl-CoA dehydrogenase type-2
O75531	9.745	0.024	Barrier-to-autointegration factor
Q14697	21.165	0.025	Neutral alpha-glucosidase AB
P62263	6.347	0.025	40S ribosomal protein S14
P0DMV9	2.049	0.026	Heat shock 70 kDa protein 1B
P29034	6.458	0.026	Protein S100-A2
P62888	2.893	0.026	60S ribosomal protein L30
Q6IBT3	23.335	0.027	T-complex protein 1 subunit eta
P47756	2.818	0.027	F-actin-capping protein subunit beta
P35222	7.555	0.028	Catenin beta-1
P07339	5.983	0.029	Cathepsin D
Q86SZ7	4.151	0.029	Proteasome activator complex subunit 2
P15311	3.903	0.029	Ezrin;Tyrosine-protein kinase receptor
P59665	4.537	0.029	Neutrophil defensin 1
P09960	5.492	0.030	Leukotriene A-4 hydrolase
P63220	4.048	0.030	40S ribosomal protein S21
Q16658	114.974	0.031	Fascin
P07954	5.399	0.032	Fumarate hydratase, mitochondrial
P54819	4.652	0.034	Adenylate kinase 2, mitochondrial
P07737	1.223	0.034	Profilin-1
P63313	5.261	0.034	Thymosin beta-10
P21796	3.716	0.034	Voltage-dependent anion-selective channel protein 1
P61247	12.449	0.035	40S ribosomal protein S3a
P14618	1.508	0.035	Pyruvate kinase
P61626	4.029	0.036	Lysozyme;Lysozyme C
Q15181	8.459	0.037	Inorganic pyrophosphatase
P27348	3.220	0.037	14-3-3 protein theta
P49411	14.069	0.037	Elongation factor Tu, mitochondrial
P05164	10.019	0.037	Myeloperoxidase
P61160	5.976	0.038	Actin-related protein 2
Q04917	4.768	0.039	14-3-3 protein eta
P62805	1.761	0.039	Histone H4
P26373	3.700	0.040	60S ribosomal protein L13
Q14204	2.799	0.041	Cytoplasmic dynein 1 heavy chain 1
P56537	7.504	0.041	Eukaryotic translation initiation factor 6
P08708	10.144	0.042	40S ribosomal protein S17
P15153	2.613	0.042	Ras-related C3 botulinum toxin substrate 2
P31949	2.100	0.045	Protein S100
P36952	6.679	0.046	Serpin B5
Q15149	4.694	0.047	Plectin
P46779	6.182	0.048	60S ribosomal protein L28
Q59FH0	5.442	0.048	Histone H2A
P62937	1.778	0.049	Peptidyl-prolyl cis–trans isomerase
P07741	5.077	0.049	Adenine phosphoribosyltransferase
P62269	3.688	0.050	40S ribosomal protein S18

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ISSN: 1559-0275

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