Identification of prothymosin alpha (PTMA) as a biomarker for esophageal squamous cell carcinoma (ESCC) by label-free quantitative proteomics and Quantitative Dot Blot (QDB)

Zhu, Yanping; Qi, Xiaoying; Yu, Cuicui; Yu, Shoujun; Zhang, Chao; Zhang, Yuan; Liu, Xiuxiu; Xu, Yuxue; Yang, Chunhua; Jiang, Wenguo; Tian, Geng; Li, Xuri; Bergquist, Jonas; Zhang, Jiandi; Wang, Lei; Mi, Jia

doi:10.1186/s12014-019-9232-6

Clinical Proteomics

Table 4 List of 40 proteins that were low-expressed in ESCC tissues

From: Identification of prothymosin alpha (PTMA) as a biomarker for esophageal squamous cell carcinoma (ESCC) by label-free quantitative proteomics and Quantitative Dot Blot (QDB)

IDs	Log ratio	P value	Protein names
P55268	0.078	0.001	Laminin subunit beta-2
Q13361	0.000	0.001	Microfibrillar-associated protein 5
O95682	0.000	0.001	Tenascin-X
P12277	0.024	0.001	Creatine kinase B-type
P20774	0.018	0.002	Mimecan
P06396	0.501	0.002	Gelsolin
O75106	0.000	0.002	Membrane primary amine oxidase
P60660	0.260	0.002	Myosin light polypeptide 6
P51884	0.118	0.003	Lumican
P35555	0.183	0.003	Fibrillin-1
Q5U0D2	0.081	0.004	Transgelin
P35749	0.029	0.004	Myosin-11
P51888	0.032	0.004	Prolargin
P24844	0.033	0.005	Myosin regulatory light polypeptide 9
P17661	0.063	0.005	Desmin
P98160	0.213	0.006	Basement membrane-specific heparan sulfate proteoglycan core protein
P12109	0.299	0.006	Collagen alpha-1(VI) chain
Q07507	0.084	0.006	Dermatopontin
P11047	0.209	0.006	Laminin subunit gamma-1
Q6ZN40	0.114	0.006	CDNA FLJ16459 fis
P18206	0.259	0.008	Vinculin
Q14112	0.065	0.010	Nidogen-2
P21291	0.086	0.011	Cysteine and glycine-rich protein 1
P68032	0.312	0.011	Actin, alpha cardiac muscle 1
Q9NZN4	0.000	0.012	EH domain-containing protein 2
P07585	0.087	0.012	Decorin
Q15746	0.021	0.014	Myosin light chain kinase, smooth muscle
Q9Y490	0.318	0.015	Talin-1
P12110	0.223	0.016	Collagen alpha-2(VI) chain
P21810	0.235	0.020	Biglycan
Q93052	0.048	0.021	Lipoma-preferred partner
P30086	0.507	0.021	Phosphatidylethanolamine-binding protein 1
P62736	0.043	0.022	Actin, aortic smooth muscle
Q96AC1	0.029	0.023	Fermitin family homolog 2
Q6NZI2	0.213	0.025	Polymerase I and transcript release factor
Q59F18	0.000	0.027	Smoothelin isoform b variant
O14558	0.000	0.027	Heat shock protein beta-6
Q13642	0.004	0.028	Four and a half LIM domains protein 1
P12111	0.321	0.031	Collagen alpha-3(VI) chain
P29536	0.000	0.032	Leiomodin-1
P05556	0.416	0.033	Integrin beta-1
Q15124	0.000	0.033	Phosphoglucomutase-like protein 5
P21333	0.213	0.033	Filamin-A
Q53GG5	0.013	0.036	PDZ and LIM domain protein 3
P01009	0.429	0.037	Alpha-1-antitrypsin;Short peptide from AAT
P43121	0.000	0.038	Cell surface glycoprotein MUC18
P52943	0.210	0.041	Cysteine-rich protein 2
P08294	0.000	0.043	Extracellular superoxide dismutase [Cu–Zn]
P56539	0.155	0.043	Caveolin
O15061	0.000	0.045	Synemin
Q9NR12	0.044	0.047	PDZ and LIM domain protein 7

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ISSN: 1559-0275

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