Group | Category | Cutoffs for filtering | LG versus N | HG versus N | HG versus LG |
---|---|---|---|---|---|
Individual proteins | Total | Quantified in all samples | 3642 | 3642 | 3642 |
Differential | q < 0.05; |Log2FC| > 0.5 | 197 | 309 | 33 | |
Up | q < 0.05; Log2FC > 0.5 | 54a | 94b | 4 | |
Down | q < 0.05; Log2FC < − 0.5 | 143c | 215c | 29 | |
CORUM complexes for differential expression analysis | Total | Quantified subunits ≥ 2; subunit coverage ≥ 50% | 852 | 852 | 852 |
Differential | q < 0.05; |Log2FC| > 0.31 | 54 | 85 | 6 | |
Up | q < 0.05; log2FC > 0.31 | 7 | 34d | 1 | |
Down | q < 0.05; Log2FC <  − 0.31 | 47e | 51e | 5 | |
CORUM complexes for differential co-regulation analysis | Total | Quantified subunits ≥ 2; subunit coverage ≥ 50%; PPI coverage ≥ 50% | 475 | 475 | 475 |
Differential | q < 0.05; |mean Z score difference| > 0.7 | 28 | 22 | 22 | |
Up | q < 0.05; mean Z score difference > 0.7 | 20f | 17g | 10 | |
Down | q < 0.05; mean Z score difference <  − 0.7 | 8 | 5 | 12 |