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Table 2 Differences in the glycopattern of serum proteins between adenocarcinoma groups and healthy control by the lectin microarray analysis based on data of 18 lectins giving significant differences

From: Stage-associated differences in the serum N- and O-glycan profiles of patients with non-small cell lung cancer

Lectin Specificity Fold change
I/II Adenocarcinoma/healthy III Adenocarcinoma/healthy IV Adenocarcinoma/healthy
Jacalin Galβ1-3GalNAcα-Ser/Thr(T), sialyl-T(ST) 1.68 1.86*** 2.11**
HHL High-Mannose, Manα1-3Man, Manα1-6Man, Man5-GlcNAc2-Asn 2.85** 3.16* 3.13*
PTL-I GalNAc, GalNAcα-1, 3Gal, GalNAcα-1, 3Galβ-1,3/4Glc 3.49** 3.85** 2.81*
SJA Terminal in GalNAc and Gal 2.98** 2.73** 1.55
AAL Fucα1-6GlcNAc(core fucose), Fucα1-3 (Galβ1-4) GlcNAc 2.09*** 2.71** 3.57**
LTL Fucα1-2Galβ1-4GlcNAc, Fucα1-3(Galβ1-4) GlcNAc 0*** 0*** 0**
GSL-I αGalNAc,GalNAcα-Ser/Thr (Tn) and αGal /** /** /***
DBA GalNAcα-Ser/Thr(Tn) and GalNAcα1-3Gal 4.27*
RCA-120 β-Gal, Galβ-1, 4GlcNAc(type II), Galβ1-3GlcNAc (type I) 0.13** 0.10*** 0.09**
STL Trimers and tetramers of GlcNAc, core (GlcNAc) of N-glycan, oligosaccharide containing GlcNAc and MurNAc 0.43** 0.45** 0.44**
BS-I αGal and αGalNAc /*** /*** /**
ConA High-Mannose, Manα1-6(Manα1-3)Man, terminal GlcNAc 0.35*** 0.35*** 0.36***
DSA β-D-GlcNAc, (GlcNAcβ1-4)n, Galβ1-4GlcNAc 3.77*** 3.62*** 3.49***
SBA Terminal GalNAc (especially GalNAcα1-3Gal) 11.75*** 13.96*** 16.31***
PSA α-D-Man, Fucα-1, 6GlcNAc (core fucose), α-D-Glc 9.36** 5.92*** 6.20**
UEA-I Fucα1-2Galβ1-4GlcNAc 7.99 5.29*** 4.46**
MAL-I Galβ-1,4GlcNAc, Siaα2-3Gal, Galβ1-3GlcNAc, Siaα2-3 /** /*** /***
BPL Galβ1-3GalNAc, terminal GalNAc /** /* /*
  1. –, no significant difference; /, the denominator of the fold change was zero
  2. *P < 0.05, **P < 0.01, ***P < 0.001