Plasma proteomic and autoantibody profiles reveal the proteomic characteristics involved in longevity families in Bama, China

Table 2 Differentially expressed proteins in the longevous and normal groups detected by TMT-based proteomic technique

No.	Name	Ratio^a	P-value^a	Protein description	MW^b (kDa)
1	LPA	0.66	0.016	Lipoprotein A	501.31
2	DEFA3	0.708	0.026	Defensin 3	10.245
3	IGHV4-4	0.72	0.019	Immunoglobulin heavy chain V-II region	13.016
4	IGKV4-1	0.774	0.028	Immunoglobulin kappa variable 4-1	13.38
5	IGHV3-15	0.789	0.018	Immunoglobulin heavy variable 3-15	12.926
6	IGHV3-7	0.799	0.017	Immunoglobulin heavy variable 3-7	12.943
7	IGHV1-2	0.833	0.011	Immunoglobulin heavy variable 1-2	13.085
8	BLVRB	0.802	0.028	Biliverdin reductase B	22.119
9	PDIA3	0.809	0.014	Protein disulfide-isomerase A3	56.782
10	TPM1	1.204	0.033	Tropomyosin alpha-1 chain	25.47
11	TPM3	1.336	0.022	Tropomyosin alpha-3 chain	33.222
12	GBA	1.207	0.002	Glucosylceramidase	50.263
13	DSG2	1.214	0.010	Desmoglein-2	122.29
14	SRC	1.296	0.013	Proto-oncogene tyrosine-protein kinase Src	59.834
15	CHGA	1.352	0.000	Chromogranin-A	50.688
16	ITGB3	1.376	0.027	Integrin beta 3	86.869
17	TAGLN2	1.441	0.026	Transgelin-2	21.086

^aDifferentially expressed proteins and were defined as having fold changes (Longevous/Normal ratio) > 1.2 (> 1.20 increased or < 0.83 decreased). A two tail Student’s T-test was performed and a p-value < 0.05 was considered to be statistically significant
^bMW, molecular weight of the differentially expressed proteins

ISSN: 1559-0275