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Table 3 106 differential proteins associated with sperm function

From: Differential motility parameters and identification of proteomic profiles of human sperm cryopreserved with cryostraw and cryovial

Protein ID

Protein name

CS/C

CV/C

CV/CS

ACE

Angiotensin-converting enzyme

0.59

0.48

N/A

ACR

Acrosin

0.32

0.39

N/A

ACRBP

Acrosin-binding protein

N/A

0.49

N/A

ACSBG2

Long-chain-fatty-acid–CoA ligase ACSBG2

0.46

0.54

N/A

ACTR1A

Alpha-centractin

0.27

0.18

N/A

AKAP3

A-kinase anchor protein 3

4.07

3.56

N/A

ARSA

Arylsulfatase A

0.48

0.48

N/A

ATP5D

ATP synthase subunit delta, mitochondrial

N/A

1.68

N/A

ATP5H

ATP synthase subunit d, mitochondrial

2.58

N/A

0.82

ATP5 J

ATP synthase-coupling factor 6, mitochondrial

1.94

1.50

N/A

BSPH1

Binder of sperm protein homolog 1

N/A

0.40

0.45

C21orf33

ES1 protein homolog, mitochondrial

N/A

0.45

0.49

C9orf9

Uncharacterized protein C9orf9

2.33

2.32

N/A

CABYR

Calcium-binding tyrosine phosphorylation-regulated protein

0.31

N/A

N/A

CALR

Calreticulin

0.39

0.36

N/A

CCDC108

Coiled-coil domain-containing protein 108

N/A

N/A

N/A

CCDC136

Isoform 4 of Coiled-coil domain-containing protein 136

2.63

2.93

N/A

CCDC147

Coiled-coil domain-containing protein 147

2.35

2.30

N/A

COX4I1

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1.99

1.60

N/A

COX5B

Cytochrome c oxidase subunit 5B, mitochondrial

2.60

2.34

N/A

COX6B1

Cytochrome c oxidase subunit 6B1

2.18

N/A

N/A

CRISP2

Cysteine-rich secretory protein 2

0.59

N/A

N/A

CTSG

Cathepsin G

N/A

0.64

N/A

CYCS

Cytochrome c (Fragment)

5.40

3.19

1.25

CYLC2

Cylicin-2

N/A

2.07

N/A

DNALI1

Axonemal dynein light intermediate polypeptide 1

2.99

2.67

N/A

DPCD

Protein DPCD

0.45

0.44

N/A

DPEP3

Dipeptidase 3

0.44

N/A

N/A

DPY19L2

Probable C-mannosyltransferase DPY19L2

6.52

5.44

N/A

ELSPBP1

Epididymal sperm-binding protein 1

4.95

5.02

N/A

FKBP1A

Peptidyl-prolyl cis–trans isomerase FKBP1A

0.47

N/A

N/A

FSCN3

Fascin-3

4.63

3.88

N/A

FSIP2

Fibrous sheath-interacting protein 2

2.17

1.99

N/A

GNPDA1

Glucosamine-6-phosphate isomerase 1

N/A

0.33

N/A

HSF2BP

Heat shock factor 2-binding protein

2.28

N/A

N/A

HSP90B1

Endoplasmin

0.29

0.37

N/A

HSPA2

Heat shock-related 70 kDa protein 2

0.19

0.23

N/A

HSPA5

78 kDa glucose-regulated protein

0.29

0.36

N/A

IMMT

Isoform 4 of Mitochondrial inner membrane protein

2.08

N/A

N/A

KLHL10

Kelch-like protein 10

0.43

0.50

N/A

KRT9

Keratin, type I cytoskeletal 9

7.83

N/A

N/A

LDHC

L-lactate dehydrogenase C chain

0.16

0.19

N/A

MNS1

Meiosis-specific nuclear structural protein 1

N/A

0.48

N/A

MPC1L

Mitochondrial pyruvate carrier 1-like protein

N/A

2.74

N/A

MRPS36

28S ribosomal protein S36, mitochondrial

N/A

0.53

N/A

NAMPT

Nicotinamide phosphoribosyltransferase

0.43

0.70

1.47

NDUFA4

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4

2.13

N/A

N/A

NDUFS3

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1.67

N/A

N/A

NUP62

Nuclear pore glycoprotein p62

0.48

0.39

N/A

OAZ3

Ornithine decarboxylase antizyme 3

2.83

3.14

N/A

PAFAH1B3

Platelet-activating factor acetylhydrolase IB subunit gamma

N/A

0.49

N/A

PATE1

Prostate and testis expressed protein 1

2.08

2.11

N/A

PATE4

Prostate and testis expressed protein 4

2.09

1.99

N/A

PGAM2

Phosphoglycerate mutase 2

0.45

0.33

N/A

PGK1

Phosphoglycerate kinase 1

0.40

0.56

N/A

PGK2

Phosphoglycerate kinase 2

0.34

0.38

N/A

PHB2

Prohibitin-2

1.99

N/A

N/A

PHGDH

D-3-phosphoglycerate dehydrogenase

N/A

2.20

N/A

PMFBP1

Isoform 2 of Polyamine-modulated factor 1-binding protein 1

4.38

3.82

N/A

PPP4R1

Serine/threonine-protein phosphatase 4 regulatory subunit 1

0.68

N/A

N/A

PRDX4

Peroxiredoxin-4

N/A

0.41

N/A

PREP

Prolyl endopeptidase

0.57

N/A

N/A

PRKACA

cAMP-dependent protein kinase catalytic subunit alpha

0.43

0.44

N/A

PRSS37

Probable inactive serine protease 37

0.39

N/A

N/A

PRTN3

Myeloblastin

N/A

0.66

N/A

PSMA1

Proteasome subunit alpha type-1

0.58

0.52

N/A

PSMA2

Proteasome subunit alpha type-2

0.32

0.31

N/A

PSMA3

Proteasome subunit alpha type-3

0.65

0.62

N/A

PSMA4

Proteasome subunit alpha type-4

0.40

0.38

N/A

PSMA5

Proteasome subunit alpha type-5

0.45

0.37

N/A

PSMB1

Proteasome subunit beta type-1

0.37

0.35

N/A

PSMB4

Proteasome subunit beta type-4

0.25

0.22

N/A

PSMB5

Proteasome subunit beta type-5

0.41

0.44

N/A

PSMB7

Proteasome subunit beta type-7

0.38

0.44

N/A

RAD23B

UV excision repair protein RAD23 homolog B

0.22

0.31

N/A

RDH16

Retinol dehydrogenase 16

N/A

1.59

N/A

ROPN1B

Ropporin-1B

4.20

N/A

N/A

RUVBL1

RuvB-like 1

0.26

0.26

N/A

SEMG1

Semenogelin-1

N/A

0.55

0.55

SEPHS1

Selenide, water dikinase 1

0.44

0.59

N/A

SEPT4

Septin-4

1.73

N/A

N/A

SLPI

Antileukoproteinase

4.90

N/A

N/A

SMCP

Sperm mitochondrial-associated cysteine-rich protein

N/A

3.08

N/A

SMRP1

Spermatid-specific manchette-related protein 1

1.55

N/A

N/A

SOD1

Superoxide dismutase [Cu–Zn]

0.14

0.17

N/A

SPA17

Sperm surface protein Sp17

2.06

1.88

N/A

SPAG6

Isoform 3 of Sperm-associated antigen 6

2.53

N/A

N/A

SPANXA1

Sperm protein associated with the nucleus on the X chromosome A

N/A

5.43

N/A

SPANXB1

Sperm protein associated with the nucleus on the X chromosome B/F

3.95

4.14

N/A

SPATA6

Spermatogenesis-associated protein 6

3.98

N/A

N/A

SPEM1

Spermatid maturation protein 1

2.69

2.13

N/A

SPINT3

Kunitz-type protease inhibitor 3

N/A

3.25

N/A

STOM

Erythrocyte band 7 integral membrane protein

N/A

0.50

N/A

TCP11

T-complex protein 11 homolog

2.06

N/A

N/A

TEKT1

Tektin-1

2.18

N/A

N/A

TEKT2

Tektin-2

4.35

2.86

1.16

TEKT3

Tektin-3

1.81

N/A

N/A

TEKT4

Tektin-4

2.13

2.05

N/A

TEKT5

Tektin-5

N/A

2.32

N/A

TSGA10

Testis-specific gene 10 protein

10.58

9.59

N/A

TXNDC2

Thioredoxin domain-containing protein 2

0.41

0.37

N/A

VAT1

Synaptic vesicle membrane protein VAT-1 homolog

0.60

0.64

N/A

VDAC3

Voltage-dependent anion-selective channel protein 3

2.41

N/A

N/A

WFDC8

WAP four-disulfide core domain protein 8

3.12

2.39

N/A

ZPBP1

Zona pellucida-binding protein 1

N/A

0.41

N/A

ZPBP2

Zona pellucida-binding protein 2

0.42

0.54

N/A

  1. CS/C, The fold of change between cryostraw (CS) and control (C); CV/C, The fold of change between cryovial (CV) and control (C); CV/CS, The fold of change between cryovial (CV) and cryostraw (CS)