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Table 2 The summary of ROC analysis of PZ, SHBG, VWF and CA19-9

From: Predictive proteomic signatures for response of pancreatic cancer patients receiving chemotherapy

Marker Stages III and IV Stage III Stage IV
AUC Sensitivity at 90% specificity Specificity at 90% sensitivity AUC Sensitivity at 90% specificity Specificity at 90% sensitivity AUC Sensitivity at 90% specificity Specificity at 90% sensitivity
PZ 0.60 0.22 0.06 0.68 0 0.50 0.46 0 0.10
SHBG 0.60 0.27 0 0.57 0.27 0 0.69 0.33 0.28
VWF 0.59 0.08 0.04 0.72 0.09 0.38 0.49 0.20 0.17
CA19-9 0.65 0.23 0.38 0.58 0.18 0.50 0.65 0.20 0.44
PZ + CA19-9 0.66 0.22 0.33 0.73 0 0.625 0.70 0 0.40
SHBG + CA19-9 0.62 0.12 0.38 0.72 0.45 0.25 0.78 0.33 0.22
VWF + CA19-9 0.67 0.19 0.38 0.73 0.09 0.5 0.69 0.20 0.50
PZ + SHBG 0.60 0.17 0.22 0.70 0.18 0.5 0.79 0.43 0.30
PZ + VWF 0.64 0.11 0.22 0.72 0 0.50 0.46 0 0.10
SHBG + VWF 0.58 0.08 0.04 0.80 0.36 0.38 0.72 0.47 0.33
PZ + SHBG + CA19-9 0.64 0.17 0.33 0.78 0.27 0.50 0.87 0.86 0.40
PZ + VWF + CA19-9 0.73 0.11 0.39 0.77 0 0.75 0.70 0.29 0.40
SHBG + VWF + CA19-9 0.68 0.23 0.38 0.83 0.36 0.50 0.77 0.47 0.22
PZ + SHBG + VWF 0.65 0.17 0.33 0.75 0.18 0.50 0.80 0.86 0.40
PZ + SHBG + VWF + CA19-9 0.71 0.11 0.39 0.83 0.27 0.63 0.87 0.71 0.30
  1. These proteins were tested as single or composite biomarker for predicting Good-responders from Limited-responders with or without inclusion of CA 19-9. PZ is a vitamin K-dependent glycoprotein, which regulates blood coagulation. SHBG is a glycoprotein that binds hormones, which is an index of testosterone level and an inflammatory marker. VWF is a blood glycoprotein maintaining hemostasis, which also acts in inflammation and antitumor