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Table 2 STRING analysis of Biological Process of Gene Symbol distributions from the TRYP and TRYP STYP where delta and χ2 were both greater than 9 after correction

From: The plasma peptides of breast versus ovarian cancer

#Term ID

Term description

Observed gene count

Background gene count

False discovery rate

O:0016043

Cellular component organization

551

5163

4.00E−09

O:0071840

Cellular component organization or biogenesis

567

5342

4.00E−09

O:0007017

Microtubule-based process

106

605

1.17E−08

O:0051641

Cellular localization

267

2180

7.59E−08

O:0006996

Organelle organization

356

3131

8.96E−08

O:0007010

Cytoskeleton organization

139

953

3.36E−07

O:0007018

Microtubule-based movement

57

276

3.34E−06

O:0007399

Nervous system development

257

2206

7.50E−06

O:0008104

Protein localization

230

1966

3.52E−05

O:0120036

Plasma membrane bounded cell projection organization

138

1034

3.52E−05

O:0048731

System development

427

4144

4.68E−05

O:0033036

Macromolecule localization

257

2268

4.69E−05

O:0070727

Cellular macromolecule localization

171

1374

4.83E−05

O:0030030

Cell projection organization

140

1067

4.96E−05

O:0034613

Cellular protein localization

169

1367

7.45E−05

O:0009987

Cellular process

1271

14652

0.00013

O:0051179

Localization

516

5233

0.00015

O:0043170

Macromolecule metabolic process

702

7453

0.00018

O:0007275

Multicellular organism development

470

4726

0.00025

O:0032502

Developmental process

528

5401

0.00025

O:0051649

Establishment of localization in cell

189

1616

0.0003

O:0046907

Intracellular transport

167

1390

0.00031

O:0090304

Nucleic acid metabolic process

399

3941

0.00043

O:0051128

Regulation of cellular component organization

252

2306

0.00047

O:0007156

Homophilic cell adhesion via plasma membrane adhesion molecules

34

158

0.00063

O:0048856

Anatomical structure development

496

5085

0.00066

O:0006139

Nucleobase-containing compound metabolic process

449

4551

0.00082

O:0007155

Cell adhesion

110

843

0.00082

O:0006928

Movement of cell or subcellular component

160

1355

0.001

O:0051276

Chromosome organization

125

999

0.001

O:0097435

Supramolecular fiber organization

60

383

0.0012

O:0046483

Heterocycle metabolic process

459

4716

0.002

O:0048666

Neuron development

99

758

0.002

O:0000226

Microtubule cytoskeleton organization

60

393

0.0022

O:0019219

Regulation of nucleobase-containing compound metabolic process

408

4133

0.0022

O:0044260

Cellular macromolecule metabolic process

602

6413

0.0022

O:0051130

Positive regulation of cellular component organization

135

1128

0.0025

O:0006725

Cellular aromatic compound metabolic process

460

4754

0.0028

O:0060255

Regulation of macromolecule metabolic process

572

6072

0.0028

O:0098609

Cell–cell adhesion

62

416

0.0028

O:0044085

Cellular component biogenesis

267

2556

0.0029

O:0051252

Regulation of RNA metabolic process

385

3890

0.0029

O:0010468

Regulation of gene expression

440

4533

0.0033

O:0022607

Cellular component assembly

247

2343

0.0034

O:0048699

Generation of neurons

162

1422

0.0034

O:0071166

Ribonucleoprotein complex localization

27

125

0.0034

O:0030182

Neuron differentiation

115

940

0.0038

O:0032989

Cellular component morphogenesis

93

720

0.0038

O:0098742

Cell–cell adhesion via plasma-membrane adhesion molecules

40

230

0.0038

O:0031175

Neuron projection development

82

616

0.0043

O:0006611

Protein export from nucleus

29

144

0.0048

O:0016070

RNA metabolic process

342

3430

0.0048

O:0031323

Regulation of cellular metabolic process

569

6082

0.0048

O:0050794

Regulation of cellular process

929

10484

0.0048

O:1901360

Organic cyclic compound metabolic process

474

4963

0.0049

O:0051168

Nuclear export

31

161

0.005

O:0080090

Regulation of primary metabolic process

560

5982

0.005

O:0051640

Organelle localization

77

574

0.0051

O:0006403

RNA localization

37

211

0.0053

O:0019222

Regulation of metabolic process

604

6516

0.0053

O:0035023

Regulation of Rho protein signal transduction

27

131

0.0053

O:2000112

Regulation of cellular macromolecule biosynthetic process

395

4050

0.0053

O:0000902

Cell morphogenesis

82

626

0.0054

O:0051171

Regulation of nitrogen compound metabolic process

546

5827

0.0054

O:0071426

Ribonucleoprotein complex export from nucleus

26

124

0.0054

O:0033043

Regulation of organelle organization

134

1155

0.0058

O:0048468

Cell development

166

1493

0.0058

O:0050658

RNA transport

34

189

0.006

O:0006355

Regulation of transcription, DNA-templated

360

3661

0.0061

O:0006405

RNA export from nucleus

27

134

0.0061

O:0010467

Gene expression

366

3733

0.0061

O:0022008

Neurogenesis

168

1519

0.0061

O:0051056

Regulation of small TPase mediated signal transduction

48

310

0.0061

O:0065007

Biological regulation

1026

11740

0.0061

O:0003205

Cardiac chamber development

31

166

0.0062

O:1903506

Regulation of nucleic acid-templated transcription

361

3683

0.0068

O:0010556

Regulation of macromolecule biosynthetic process

400

4143

0.0079

O:0006406

mRNA export from nucleus

23

107

0.0083

O:0015833

Peptide transport

157

1416

0.0084

O:0032501

Multicellular organismal process

599

6507

0.0092

O:0051493

Regulation of cytoskeleton organization

65

477

0.0092

  1. The protein–protein interaction statistics were: 485 nodes; 1148 edges; average node degree, 4.73; avg. local clustering coefficient, 0.325; expected number of edges: 851; PPI enrichment p-value: < 1.0e−16