Skip to main content

Table 1 An overview of upregulated proteins identified in Merkel cell carcinoma cell lines

From: Quantitative proteome analysis of Merkel cell carcinoma cell lines using SILAC

Cell lineUniProt entry nameProtein nameGene symbolRatio (H/L)
BroLiMFRN1_HUMANMitoferrin-1SLC25A379.64
SF01_HUMANSplicing factor 1SF11.92
N4BP1_HUMANNEDD4-binding protein 1N4BP11.65
MKL-1H2A1H_HUMANHistone H2A type 1-HHIST1H2AH5.25
HMGN2_HUMANNon-histone chromosomal protein HMG-17HMGN23.86
C2C2L_HUMANC2 domain-containing protein 2-likeC2CD2L3.63
DPY30_HUMANProtein dpy-30 homologDPY303.56
STON1_HUMANStonin-1STON13.18
PREX2_HUMANPhosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 proteinPREX23.11
CCAR1_HUMANCell division cycle and apoptosis regulator protein 1CCAR12.96
RFC1_HUMANReplication factor C subunit 1RFC12.89
ATPB_HUMANATP synthase subunit beta, mitochondrialATP5B2.87
ROAA_HUMANHeterogeneous nuclear ribonucleoprotein A/BHNRNPAB2.64
DJB14_HUMANDnaJ homolog subfamily B member 14DNAJB142.53
SF3B1_HUMANSplicing factor 3B subunit 1SF3B12.47
RL29_HUMAN60S ribosomal protein L29RPL292.44
HNRPM_HUMANHeterogeneous nuclear ribonucleoprotein MHNRNPM2.39
SUMO4_HUMANSmall ubiquitin-related modifier 4SUMO42.38
NDUS7_HUMANNADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialNDUFS72.29
HSP7C_HUMANHeat shock cognate 71 kDa proteinHSPA82.19
CH60_HUMAN60 kDa heat shock protein, mitochondrialHSPD12.10
BSDC1_HUMANBSD domain-containing protein 1BSDC12.06
RS30_HUMAN40S ribosomal protein S30FAU2.01
MXRA5_HUMANMatrix-remodeling-associated protein 5MXRA51.96
ROA2_HUMANHeterogeneous nuclear ribonucleoproteins A2/B1HNRNPA2B11.89
ROA1_HUMANHeterogeneous nuclear ribonucleoprotein A1HNRNPA11.89
ROA3_HUMANHeterogeneous nuclear ribonucleoprotein A3HNRNPA31.89
NPM_HUMANNucleophosminNPM11.80
CH10_HUMAN10 kDa heat shock protein, mitochondrialHSPE11.70
STK24_HUMANSerine/threonine-protein kinase 24STK241.70
HNRPC_HUMANHeterogeneous nuclear ribonucleoproteins C1/C2HNRNPC1.66
H2B1O_HUMANHistone H2B type 1-OHIST1H2BO1.60
PABP1_HUMANPolyadenylate-binding protein 1PABPC11.58
I23O2_HUMANIndoleamine 2,3-dioxygenase 2IDO21.54
MKL-2PADI6_HUMANProtein-arginine deiminase type-6PADI6 PAD69.47
CTL2_HUMANCholine transporter-like protein 2SLC44A26.74
SRSF3_HUMANSerine/arginine-rich splicing factor 3SRSF35.87
HMGN2_HUMANNon-histone chromosomal protein HMG-17HMGN25.10
PABP1_HUMANPolyadenylate-binding protein 1PABPC14.02
NDUS7_HUMANNADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialNDUFS73.84
H2B1H_HUMANHistone H2B type 1-HHIST1H2BH3.15
COF1_HUMANCofilin-1CFL12.30
LRRT3_HUMANLeucine-rich repeat transmembrane neuronal protein 3LRRTM32.27
CH10_HUMAN10 kDa heat shock protein, mitochondrialHSPE12.20
ACM2_HUMANMuscarinic acetylcholine receptor M2CHRM22.14
S38AA_HUMANPutative sodium-coupled neutral amino acid transporter 10SLC38A102.14
ROA1_HUMANHeterogeneous nuclear ribonucleoprotein A1HNRNPA12.08
WDR62_HUMANWD repeat-containing protein 62WDR622.02
ROA2_HUMANHeterogeneous nuclear ribonucleoproteins A2/B1HNRNPA2B12.01
STMN1_HUMANStathminSTMN11.80
TM266_HUMANTransmembrane protein 266TMEM2661.77
H2B2E_HUMANHistone H2B type 2-EHIST2H2BE1.66
TBA1A_HUMANTubulin alpha-1A chainTUBA1A1.64
TBA1B_HUMANTubulin alpha-1B chainTUBA1B1.64
HNRPK_HUMANHeterogeneous nuclear ribonucleoprotein KHNRNPK1.60
PRDX2_HUMANPeroxiredoxin-2PRDX21.50
PeTaROA2_HUMANHeterogeneous nuclear ribonucleoproteins A2/B1HNRNPA2B14.46
ROA3_HUMANHeterogeneous nuclear ribonucleoprotein A3HNRNPA34.46
H2A1B_HUMANHistone H2A type 1-B/EHIST1H2AB4.23
H2AJ_HUMANHistone H2A.JH2AFJ4.23
ROA1_HUMANHeterogeneous nuclear ribonucleoprotein A1HNRNPA12.98
NIBL1_HUMANNiban-like protein 1FAM129B2.97
CTL2_HUMANCholine transporter-like protein 2SLC44A22.96
REPS2_HUMANRalBP1-associated Eps domain-containing protein 2REPS22.72
URGCP_HUMANUp-regulator of cell proliferationURGCP2.69
H14_HUMANHistone H1.4HIST1H1E2.67
H33_HUMANHistone H3.3H3F3A2.39
K0895_HUMANUncharacterized protein KIAA0895KIAA08952.36
H15_HUMANHistone H1.5HIST1H1B2.17
H2B1N_HUMANHistone H2B type 1-NHIST1H2BN1.91
H2B2E_HUMANHistone H2B type 2-EHIST2H2BE1.90
PRDX2_HUMANPeroxiredoxin-2PRDX21.80
WaGaSLX4I_HUMANProtein SLX4IPSLX4IP33.84
TMM56_HUMANTransmembrane protein 56TMEM568.88
S38AA_HUMANPutative sodium-coupled neutral amino acid transporter 10SLC38A106.38
COQ6_HUMANUbiquinone biosynthesis monooxygenase COQ6, mitochondrialCOQ64.57
NEK5_HUMANSerine/threonine-protein kinase Nek5NEK54.36
PEX16_HUMANPeroxisomal membrane protein PEX16PEX164.33
PEAK1_HUMANPseudopodium-enriched atypical kinase 1PEAK13.95
PCBP2_HUMANPoly(rC)-binding protein 2PCBP23.83
HS71A_HUMANHeat shock 70 kDa protein 1AHSPA1A3.66
FBX41_HUMANF-box only protein 41FBXO413.59
HNRPC_HUMANHeterogeneous nuclear ribonucleoproteins C1/C2HNRNPC3.55
HMMR_HUMANHyaluronan mediated motility receptorHMMR3.37
SMYD5_HUMANSET and MYND domain-containing protein 5SMYD53.27
MBNL2_HUMANMuscleblind-like protein 2MBNL22.47
H4_HUMANHistone H4HIST1H4A2.45
HNF4A_HUMANHepatocyte nuclear factor 4-alphaHNF4A2.35
ASPG_HUMANN(4)-(beta-N-acetylglucosaminyl)-l-asparaginaseAGA2.20
H2B1O_HUMANHistone H2B type 1-OHIST1H2BO1.99
H2B1D_HUMANHistone H2B type 1-DHIST1H2BD1.97
TBB5_HUMANTubulin beta chainTUBB1.89
UGGG1_HUMANUDP-glucose:glycoprotein glucosyltransferase 1UGGT11.80
UB2J1_HUMANUbiquitin-conjugating enzyme E2 J1UBE2J11.80
RLA2_HUMAN60S acidic ribosomal protein P2RPLP21.77
SF01_HUMANSplicing factor 1SF11.71
HNRL2_HUMANHeterogeneous nuclear ribonucleoprotein U-like protein 2HNRNPUL21.71
ROAA_HUMANHeterogeneous nuclear ribonucleoprotein A/BHNRNPAB1.70
POP1_HUMANRibonucleases P/MRP protein subunit POP1POP11.69
PRDX2_HUMANPeroxiredoxin-2PRDX21.68
CE57L_HUMANCentrosomal protein CEP57L1CEP57L11.67
CCDC6_HUMANCoiled-coil domain-containing protein 6CCDC61.67
KCTD9_HUMANBTB/POZ domain-containing protein KCTD9KCTD91.66
ADCY1_HUMANAdenylate cyclase type 1ADCY11.59
S35E2_HUMANSolute carrier family 35 member E2SLC35E21.55
ATP5J_HUMANATP synthase-coupling factor 6, mitochondrialATP5J1.51
ATPA_HUMANATP synthase subunit alpha, mitochondrialATP5A11.50
MCC13CLCB_HUMANClathrin light chain BCLTB4.71
HSPB1_HUMANHeat shock protein beta-1HSPB13.23
SNX4_HUMANSorting nexin-4SNX42.83
RL23A_HUMAN60S ribosomal protein L23aRPL23A2.82
PROF1_HUMANProfilin-1PFN12.51
H2B1C_HUMANHistone H2B type 1-C/E/F/G/IHIST1H2BC2.47
ZN407_HUMANZinc finger protein 407ZNF4072.44
H2B1K_HUMANHistone H2B type 1-KHIST1H2BK2.42
OPRD_HUMANDelta-type opioid receptorOPRD12.42
HGB1A_HUMANPutative high mobility group protein B1-like 1HMGB1P12.35
PSME1_HUMANProteasome activator complex subunit 1PSME12.29
PRDX1_HUMANPeroxiredoxin-1PRDX12.22
CAC1G_HUMANVoltage-dependent T-type calcium channel subunit alpha-1GCACNA1G2.20
H2B2F_HUMANHistone H2B type 2-FHIST2H2BF2.18
K2C5_HUMANKeratin, type II cytoskeletal 5KRT52.17
RL4_HUMAN60S ribosomal protein L4RPL42.15
LDHB_HUMANl-Lactate dehydrogenase B chainLDHB2.14
MT1E_HUMANMetallothionein-1EMT1E2.14
ILRL2_HUMANInterleukin-1 receptor-like 2IL1RL21.94
MYPC2_HUMANMyosin-binding protein C, fast-typeMYBPC21.93
NONO_HUMANNon-POU domain-containing octamer-binding proteinNONO1.84
LMNA_HUMANPrelamin-A/CLMNA1.82
K2C8_HUMANKeratin, type II cytoskeletal 8KRT81.66
NUCL_HUMANNucleolinNCL1.64
PDLI1_HUMANPDZ and LIM domain protein 1PDLIM11.64
RLA1_HUMAN60S acidic ribosomal protein P1RPLP11.64
BAF_HUMANBarrier-to-autointegration factorBANF11.63
NPM_HUMANNucleophosminNPM11.61
HNRPK_HUMANHeterogeneous nuclear ribonucleoprotein KHNRNPK1.61
YBOX1_HUMANNuclease-sensitive element-binding protein 1YBX11.60
H2AJ_HUMANHistone H2A.JH2AFJ1.56
RL34_HUMAN60S ribosomal protein L34RPL341.55
ROA1_HUMANHeterogeneous nuclear ribonucleoprotein A1HNRNPA11.52
RS28_HUMAN40S ribosomal protein S28RPS281.52
CQ047_HUMANUncharacterized protein C17orf47C17orf471.52