Table 2 An overview of downregulated proteins identified in Merkel cell carcinoma cell lines
From: Quantitative proteome analysis of Merkel cell carcinoma cell lines using SILAC
Cell line | UniProt entry name | Protein name | Gene symbol | Ratio (H/L) |
|---|---|---|---|---|
BroLi | H10_HUMAN | Histone H1.0 | H1F0 | 0.45 |
MGAP_HUMAN | MAX gene-associated protein | MGA | 0.17 | |
MKL-1 | ASXL1_HUMAN | Putative Polycomb group protein ASXL1 | ASXL1 | 0.48 |
TBB5_HUMAN | Tubulin beta chain | TUBB TUBB5 | 0.48 | |
TAF2_HUMAN | Transcription initiation factor TFIID subunit 2 | TAF2 | 0.45 | |
FBLN2_HUMAN | Fibulin-2 | FBLN2 | 0.45 | |
PRDX2_HUMAN | Peroxiredoxin-2 | PRDX2 | 0.44 | |
SEPT5_HUMAN | Septin-5 | Sep-05 | 0.44 | |
FUS_HUMAN | RNA-binding protein FUS | FUS | 0.44 | |
BICD2_HUMAN | Protein bicaudal D homolog 2 | BICD2 | 0.43 | |
SRRT_HUMAN | Serrate RNA effector molecule homolog | SRRT | 0.41 | |
MAK_HUMAN | Serine/threonine-protein kinase MAK | MAK | 0.40 | |
CBX5_HUMAN | Chromobox protein homolog 5 | CBX5 | 0.36 | |
CHSP1_HUMAN | Calcium-regulated heat-stable protein 1 | CARHSP1 | 0.34 | |
NUCB2_HUMAN | Nucleobindin-2 | NUCB2 | 0.31 | |
TPIS_HUMAN | Triosephosphate isomerase | TPI1 | 0.26 | |
TRI13_HUMAN | E3 ubiquitin-protein ligase TRIM13 | TRIM13 | 0.22 | |
L37A3_HUMAN | Leucine-rich repeat-containing protein 37A3 | LRRC37A3 | 0.08 | |
CMGA_HUMAN | Chromogranin-A | CHGA | 0.03 | |
KCTD9_HUMAN | BTB/POZ domain-containing protein KCTD9 | KCTD9 | 0.02 | |
1433Z_HUMAN | 14-3-3 protein zeta/delta | YWHAZ | 0.02 | |
MKL-2 | ALAT1_HUMAN | Alanine aminotransferase 1 | GPT | 0.49 |
GRP75_HUMAN | Stress-70 protein, mitochondrial | HSPA9 | 0.40 | |
ULK2_HUMAN | Serine/threonine-protein kinase ULK2 | ULK2 | 0.34 | |
NUCL_HUMAN | Nucleolin | NCL | 0.24 | |
1433Z_HUMAN | 14-3-3 protein zeta/delta | YWHAZ | 0.04 | |
PeTa | KCTD9_HUMAN | BTB/POZ domain-containing protein KCTD9 | KCTD9 | 0.45 |
WaGa | TMX1_HUMAN | Thioredoxin-related transmembrane protein 1 | TMX1 | 0.39 |
RS30_HUMAN | 40S ribosomal protein S30 | FAU | 0.38 | |
CPLX3_HUMAN | Complexin-3 | CPLX | 0.37 | |
CA052_HUMAN | UPF0690 protein C1orf52 | C1orf52 | 0.27 | |
RSMB_HUMAN | Small nuclear ribonucleoprotein-associated proteins B and B’ | SNRPB | 0.23 | |
RS28_HUMAN | 40S ribosomal protein S28 | RPS28 | 0.22 | |
CQ047_HUMAN | Uncharacterized protein C17orf47 | C17orf47 | 0.22 | |
G3P_HUMAN | Glyceraldehyde-3-phosphate dehydrogenase | GAPDH | 0.21 | |
GRP75_HUMAN | Stress-70 protein, mitochondrial | HSPA9 | 0.17 | |
SAE2_HUMAN | SUMO-activating enzyme subunit 2 | UBA2 | 0.09 | |
SRSF7_HUMAN | Serine/arginine-rich splicing factor 7 | SRSF7 | 0.06 | |
MARCS_HUMAN | Myristoylated alanine-rich C-kinase substrate | MARCKS | 0.05 | |
MCC13 | WNK4_HUMAN | Serine/threonine-protein kinase WNK4 | WNK4 | 0.48 |
HNRPU_HUMAN | Heterogeneous nuclear ribonucleoprotein U | HNRNPU | 0.44 | |
RL18A_HUMAN | 60S ribosomal protein L18a | RPL18A | 0.42 | |
FUBP1_HUMAN | Far upstream element-binding protein 1 | FUBP1 | 0.27 |