Table 2 Cluster analysis according to observed response modes of proteins in each of the diseased states relative to normal non-cancer tissue
Group | Response | No. of proteins | PPI enrichment, p-value |
|---|---|---|---|
1 | DDD | 142 | < 1.0e−16 |
2 | DDU | 36 | 4.88E−15 |
3 | DDI | 0 | – |
4 | DUD | 25 | 1.32E−09 |
5 | DUU | 93 | 1.37E−06 |
6 | DUI | 5 | 1 |
7 | DID | 0 | – |
8 | DIU | 0 | – |
9 | DII | 2 | 1 |
10 | UDD | 198 | < 1.0e−16 |
11 | UDU | 56 | 2.81E−05 |
12 | UUD | 64 | 2.83E−12 |
13 | UDU | 0 | – |
14 | UUU | 1636 | 1.00E−16 |
15 | UUI | 78 | 3.86E−05 |
16 | UID | 0 | – |
17 | UIU | 48 | 4.25E−09 |
18 | UII | 121 | < 1.0E−16 |
19 | IDD | 5 | 1 |
20 | IDU | 0 | – |
21 | IDI | 0 | – |
22 | IUD | 2 | 1 |
23 | IUU | 104 | < 1.03−16 |
24 | IUI | 16 | 2.80E−05 |
25 | IID | 0 | – |
26 | IIU | 12 | 0.477 |
27 | III | 125 | < 1.0E−16 |