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Table 2 Proteins that show differences between AD and control groups across independent studies

From: A comprehensive systematic review of CSF proteins and peptides that define Alzheimer’s disease

Number of articles Gene (Protein)
18 APOE (APOE)$
15 VGF (VGF)
14 TTR (TTHY)$
11 CHGA (CMGA)$, CST3 (CYTC)$
10 SERPINA1 (A1AT)$, APOA1 (APOA1)$
9 C4 (CO4)$, CLU (CLUS)$, SPP1 (OSTP)$, PCSK1N (PCSK1N)
8 C3 (CO3)$
7 PTGDS (PTGDS)$, B2M (B2MG), GC (VTDB)$
6 ALB (ALBU)$, A2M (A2MG)$, APOH (APOH)$, CHI3L1 (CH3L1), NPTX1 (NPTX1), NPTXR (NPTXR), SCG2 (SCG2), RBP4 (RET4)
5 TF (TRFE)$, AGT (ANGT)$, FABP (FABPH), GSN (GELS)$, HP (HPT)$, SERPINA3 (AACT)$, CNDP1 (CNDP1)$, CP (CERU)$, CHGB (SCG1)$, ITM2B (ITM2B), SCG3 (SCG3)
4 A1BG (A1BG)$, FGB (FIBB), PLG (PLMN)$, NRXN1 (NRX1A), MDH1 (MDHC), APOD (APOD)$, CFB (CFAB)$, HPX (HEMO)$, IGFBP2 (IBP2), RETN (RETN), DAG1 (DAG1), APP (A4), FGA (FIBA), SPRC (SPARC), SPON1 (SPON1), GOT1 (AATC), APLP2 (APLP2), SCG5 (7B2), CLSTN1 (CSTN1), MCAM (MUC18), SERPINF1 (PEDF)$
3 AMBP (AMBP), ITIH1 (ITIH1), LRG1 (A2GL), MT3 (MT3), NEGR1 (NEGR1), RNASE1 (RNASE1), SORT1 (SORT), APOC1 (APOC1), ALDOA (ALDOA), C2 (CO2), PKM (KPYM), AFM (AFAM), APOA2 (APOA2)$, CLEC3B (TETN), CFD (CFAD), HGF (HGF), PPY (PAHO), PSAP (SAP),VEGF (Q9UNS8), CNTN1 (CNTN1), NCAM1 (NCAM1), SPARCL1 (SPRL1)$, CXCL16 (CXL16), SPOCK1 (TICN1), VEGFA (VEGFA), EFEMP1 (FBLN3)$, BASP1 (BASP1), KNG1 (KNG1)$, NSG1 (NSG1), PRNP (PRIO), SERPINC1 (ANT3)$, SMOC1 (SMOC1), SOD1 (SODC), APLP1 (APLP1)
2 CTSD (CATD), ACTA2 (ACTA), ATP6AP1 (VAS1), AZGP1 (ZA2G)$, C1QB (C1QB), C5 (CO5), C6 (CO6), ENO2 (ENOG), ENPP2 (ENPP2)$, IGF2 (IGF2), KLK6 (KLK6)$, LCAT (LCAT), LTBP2 (LTBP2), LYNX1 (LYNX1), NFASC (NFASC), NRGN (NEUG), NRXN3 (NRX3B), PAM (AMD), PPIB (PPIB), PTPRD (PTPRD), PTPRN (PTPRN), SEZ6L (SE6L1), TAC1 (TKN1), GAP43 (NEUM), CHL1 (NCHL1)$, ORM1 (A1AG1)$, KRT9 (K1C9), IGFBP7 (IBP7), LDLR (LDLR), MMP10 (MMP10), TNFSF10 (TNF10), ADIPOQ1 (ADIPO), CPE (CBPE), CCL16 (CCL16), CD14 (CD14), CD40 (TNR5), C7 (CO7), C1R (C1R), DCD (DCD), HRG (HRG), IGFBP6 (IBP6), INS (A6XGL2), L1CAM (L1CAM), MMP2 (MMP2), MB (MYG), NBL1 (NBL1), NPDC1 (NPDC1), NRCAM (NRCAM)$, OGN (MIME), PRL (Q5THQ0), SERPINA7 (THBG), SERPINE1 (PAI1), CNTN2 (CNTN2), CD99 (CD99), ITM2C (ITM2C), PENK (PENK), SPOCK2 (TICN2), STT (SMS), TAC (TKNK), ITIH4 (ITIH4), SOD3 (SODE), VTN (VTNC), CADM3 (CADM3), CLSTN3 (CSTN3), COL1A1 (CO1A1), FBLN1 (FBLN1)$, IGSF8 (IGSF8), NCAN (NCAN), PBXIP1 (PBIP1), PGLYRP2 (PGRP2), TGOLN2 (TGON2)
  1. The number of studies which detected these changes is included. $ proteins which are abundant in CSF of healthy individuals (Schilde et al. 2018)