Fig. 3

Proteomic alteration in distant metastatic breast cancer between molecular subtypes. a Hierarchical clustering of differentially expressed proteins (DEPs) between distant metastatic breast cancer molecular subtypes (ANOVA, p-value < 0.05). The DEPs (1086) from the pooled sample set were divided into 6 groups. Clusters of upregulated proteins are marked in red. b–d Canonical pathway enrichment of clusters 2, 4, and 6. The significant pathways (Fisher’s exact test p-value < 0.05) were deduced using Ingenuity Pathway Analysis (IPA), and their activation and inhibition states are expressed as Z-scores