Identification of TUBB2A by quantitative proteomic analysis as a novel biomarker for the prediction of distant metastatic breast cancer

Shin, Dongyoon; Park, Joonho; Han, Dohyun; Moon, Ji Hye; Ryu, Han Suk; Kim, Youngsoo

doi:10.1186/s12014-020-09280-z

Clinical Proteomics

Table 1 Detailed statistical analysis of 17 overlapping proteins

From: Identification of TUBB2A by quantitative proteomic analysis as a novel biomarker for the prediction of distant metastatic breast cancer

Protein name	Dis-meta vs non dis-meta in pooled sample set				Dis-meta vs non dis-meta in individual sample set				High invasive vs low invasive in cell lines set				Consistency of protein expression	Fold-change > 1.2
Protein name	t Test significance	p Value	Adjusted p value (BH FDR < 0.05)	Fold-change	t Test significance	p Value	Adjusted p value (BH FDR < 0.05)	Fold-change	t Test significance	p Value	Adjusted p value (BH FDR < 0.05)	Fold-change	Consistency of protein expression	Fold-change > 1.2
Glyceraldehyde-3-phosphate dehydrogenase	+	0.01308	1	1.211	+	0.03681	1	1.260	+	0.01580	0.02242	0.815	N	N
Tubulin beta-2A chain	+	0.01730	1	1.219	+	0.01980	1	1.298	+	0.00076	0.00173	2.329	Y	Y
Lactotransferrin	+	0.00000	9.269E − 09	0.581	+	0.02619	1	0.546	+	0.00529	0.00866	0.551	Y	Y
Stress-70 protein, mitochondrial	+	0.00251	0.85696	1.114	+	0.04264	1	1.160	+	0.00003	0.00019	0.742	N	N
Catenin alpha-1	+	0.04027	1	1.137	+	0.03017	1	1.189	+	0.00000	0.00003	0.473	N	N
Bifunctional purine biosynthesis protein PURH	+	0.03371	1	1.150	+	0.03078	1	1.180	+	0.00047	0.00119	0.710	N	N
Heterogeneous nuclear ribonucleoprotein H	+	0.04529	1	1.046	+	0.02779	1	1.111	N/D	N/D	N/D	N/D	N/D	N
Isoform 2 of Multifunctional protein ADE2	+	0.01657	1	1.149	+	0.02412	1	1.147	+	0.00184	0.00355	0.742	N	N
ADP/ATP translocase 3	+	0.01062	1	0.827	+	0.04718	1	0.833	+	0.00022	0.00068	1.416	N	N
Exportin-5	+	0.00720	1	1.177	+	0.03871	1	1.227	+	0.00359	0.00619	0.868	N	N
RNA-binding protein 39	+	0.04237	1	1.074	+	0.02435	1	1.119	+	0.00171	0.00334	0.916	N	N
Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain, isoform CRA_a	+	0.04319	1	0.922	+	0.01636	1	0.834	+	0.00049	0.00124	0.889	Y	N
Proteasome subunit beta type-4	+	0.00136	0.60958	1.111	+	0.03592	1	1.143	+	0.00066	0.00155	1.213	Y	N
Beta-glucuronidase	+	0.00266	0.83128	0.643	+	0.02986	1	0.630	N/D	N/D	N/D	N/D	N/D	N
Mitotic checkpoint protein BUB3	+	0.00728	1	1.113	+	0.04702	1	1.112	+	0.03503	0.04592	1.057	Y	N
Platelet-activating factor acetylhydrolase IB subunit gamma	+	0.04161	1	1.221	+	0.02117	1	1.266	+	0.01903	0.02649	0.850	N	N
2-hydroxyacyl-CoA lyase 1	+	0.01337	1	1.258	+	0.04677	1	1.314	+	0.00001	0.00010	0.575	N	N

(N/D-not detection, N-no, Y-yes)

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ISSN: 1559-0275

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