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Table 1 Subclinical rejection cohort patient characteristics, used for activity-based protein profiling

From: Activity-based protein profiling guided identification of urine proteinase 3 activity in subclinical rejection after renal transplantation

Patient characteristic All n = 18 Normal transplant n = 6 Subclinical TCMR Banff ≥ 1A n = 6 Clinical TCMR Banff ≥ 1A n = 6
At transplant
 Recipient age (years) 50.6 ± 9.8 48.7 ± 5.1 52.2 ± 4.4 50.9 ± 16.5
 Recipient sex (male) 15 (83.3) 6 (33.3) 4 (22.2) 5 (27.8)
 Recipient race (Caucasian) 17 (94.4) 5 (27.8) 6 (33.3) 6 (33.3)
Cause of end-stage renal disease
 Diabetes 4 (22.2) 3 (50.0) 0 1 (16.7)
 Glomerulonephritis 7 (38.9) 2 (33.3) 3 (50.0) 2 (33.3)
 Polycystic kidney disease or congenital 5 (27.8) 1 (16.7) 2 (33.3) 2 (33.3)
 Hypertension 1 (0.06) 0 0 1 (16.7)
 Drug toxicity (lithium) 1 (0.06) 0 1 (16.7) 0
HLA mismatch 3.78 ± 1.4 3.17 (1.8) 4.17 (1.5) 4.0 (0.9)
Panel reactive antibody (PRA) 0.78 ± 2.3 2.33 ± 3.7 0 0
Donor type (living) 12 (66.7) 3 (16.7) 3 (16.7) 6 (33.3)
Donor age (years) 39.6 ± 13.2 38.8 ± 14.8 38.3 ± 17.7 41.5 ± 7.2
Induction therapy (none/basiliximab/thymoglobulin) 13/4/1 5/0/1 4/2/0 4/2/0
Post-transplant
 Maintenance therapy: tacrolimus, mycophenolate mofetil and prednisone 14 (77.8) 6 (33.3) 4 (22.2) 4 (22.2)
 Delayed graft function (dialysis in the 1st week post-transplant) 0 0 0 0
 Biopsy time (weeks post-transplant) 15.7 ± 10.0 20.8 ± 12.0 14.3 ± 9.0 11.8 ± 7.8
 Banff i score 1.6 ± 1.0 0.3 ± 0.8 2.2 ± 0.4 2.2 ± 0.4
 Banff t score 1.7 ± 1.3 0.5 ± 1.2 2.7 ± 0.5 1.8 ± 1.0
 Banff v score 0.2 ± 0.7 0 0 0.7 ± 1.2
 Banff g score 0.2 ± 0.7 0 0 0.5 ± 1.2
 Banff ci score 0.4 ± 0.8 0.3 ± 0.5 0.5 ± 0.5 0.5 ± 1.2
 Banff ct score 0.6 ± 0.6 0.7 ± 0.5 0.5 ± 0.5 0.7 ± 0.8
 Banff cv score 0.5 ± 0.9 0.4 ± 0.9 0.3 ± 0.5 0.75 ± 1.5
 Banff cg score 0.1 ± 0.3 0.2 ± 0.4 0 0.2 ± 0.4
 Serum creatinine at biopsy (µmol/L) 137.2 ± 45.4 125.4 ± 25.6 113.0 ± 44.1 173.2 ± 44.2
 MDRD eGFR at biopsy (mL/min) 54.5 ± 18.8 59.4 ± 15.7 64.0 ± 19.1 40.1 ± 14.3
 Total urine protein (g/day) 0.19 ± 0.2 0.15 ± 0.1 0.14 ± 0.07 0.28 ± 0.3
  1. Data are reported as mean ± SD, or total count (total %)
  2. Other maintenance immunosuppression was triple therapy with cyclosporine, mycophenolate mofetil & prednisone