Patient characteristic | All n = 18 | Normal transplant n = 6 | Subclinical TCMR Banff ≥ 1A n = 6 | Clinical TCMR Banff ≥ 1A n = 6 |
---|---|---|---|---|
At transplant | ||||
Recipient age (years) | 50.6 ± 9.8 | 48.7 ± 5.1 | 52.2 ± 4.4 | 50.9 ± 16.5 |
Recipient sex (male) | 15 (83.3) | 6 (33.3) | 4 (22.2) | 5 (27.8) |
Recipient race (Caucasian) | 17 (94.4) | 5 (27.8) | 6 (33.3) | 6 (33.3) |
Cause of end-stage renal disease | ||||
Diabetes | 4 (22.2) | 3 (50.0) | 0 | 1 (16.7) |
Glomerulonephritis | 7 (38.9) | 2 (33.3) | 3 (50.0) | 2 (33.3) |
Polycystic kidney disease or congenital | 5 (27.8) | 1 (16.7) | 2 (33.3) | 2 (33.3) |
Hypertension | 1 (0.06) | 0 | 0 | 1 (16.7) |
Drug toxicity (lithium) | 1 (0.06) | 0 | 1 (16.7) | 0 |
HLA mismatch | 3.78 ± 1.4 | 3.17 (1.8) | 4.17 (1.5) | 4.0 (0.9) |
Panel reactive antibody (PRA) | 0.78 ± 2.3 | 2.33 ± 3.7 | 0 | 0 |
Donor type (living) | 12 (66.7) | 3 (16.7) | 3 (16.7) | 6 (33.3) |
Donor age (years) | 39.6 ± 13.2 | 38.8 ± 14.8 | 38.3 ± 17.7 | 41.5 ± 7.2 |
Induction therapy (none/basiliximab/thymoglobulin) | 13/4/1 | 5/0/1 | 4/2/0 | 4/2/0 |
Post-transplant | ||||
Maintenance therapy: tacrolimus, mycophenolate mofetil and prednisone | 14 (77.8) | 6 (33.3) | 4 (22.2) | 4 (22.2) |
Delayed graft function (dialysis in the 1st week post-transplant) | 0 | 0 | 0 | 0 |
Biopsy time (weeks post-transplant) | 15.7 ± 10.0 | 20.8 ± 12.0 | 14.3 ± 9.0 | 11.8 ± 7.8 |
Banff i score | 1.6 ± 1.0 | 0.3 ± 0.8 | 2.2 ± 0.4 | 2.2 ± 0.4 |
Banff t score | 1.7 ± 1.3 | 0.5 ± 1.2 | 2.7 ± 0.5 | 1.8 ± 1.0 |
Banff v score | 0.2 ± 0.7 | 0 | 0 | 0.7 ± 1.2 |
Banff g score | 0.2 ± 0.7 | 0 | 0 | 0.5 ± 1.2 |
Banff ci score | 0.4 ± 0.8 | 0.3 ± 0.5 | 0.5 ± 0.5 | 0.5 ± 1.2 |
Banff ct score | 0.6 ± 0.6 | 0.7 ± 0.5 | 0.5 ± 0.5 | 0.7 ± 0.8 |
Banff cv score | 0.5 ± 0.9 | 0.4 ± 0.9 | 0.3 ± 0.5 | 0.75 ± 1.5 |
Banff cg score | 0.1 ± 0.3 | 0.2 ± 0.4 | 0 | 0.2 ± 0.4 |
Serum creatinine at biopsy (µmol/L) | 137.2 ± 45.4 | 125.4 ± 25.6 | 113.0 ± 44.1 | 173.2 ± 44.2 |
MDRD eGFR at biopsy (mL/min) | 54.5 ± 18.8 | 59.4 ± 15.7 | 64.0 ± 19.1 | 40.1 ± 14.3 |
Total urine protein (g/day) | 0.19 ± 0.2 | 0.15 ± 0.1 | 0.14 ± 0.07 | 0.28 ± 0.3 |