Fig. 3

AD specific CSF markers reflect underlying changes in synaptic transmission, inflammation, myelination and energy metabolism. a Linear regression analyses showed a strong degree of correlation (cor = 0.71, p = 1.6E−7) between the 41 targeted proteins in AD CSF compared to control in both the discovery (TMT-MS) and replication (PRM) cohorts despite difference in sample preparation and quantitative MS platforms. Proteins with high CV (> 30%) and low CV (< 30%) are represented by red and blue circles, respectively. b Following ANOVA analyses (Tukey post hoc FDR), a total of 25 of 41 proteins (61%) were consistently and significantly increased in AD (p < 0.05) compared to controls and non-AD dementia cases. Proteins are classified by their biological and/or cell type expression profiles in brain (background color shading) as neuronal/synaptic (blue), glial/inflammation (orange), myelin (green) and metabolism (yellow). Proteins highlighted in red have a CV > 30%. Error bars represent standard error of the mean