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Fig. 3 | Clinical Proteomics

Fig. 3

From: Laser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissues

Fig. 3

The ECM comprising morphologically normal alveoli and blood vessels in IPF. a Principal component analysis (PCA) of normalised peptide intensities for the micro-dissected human lung blood vessels (red) and alveoli (blue). Numbers next to dots denote donor IDs. Values in brackets denote percentage of variance explained by each principal component (PC). b A volcano plot of all 1252 proteins or (c) ECM proteins only showing a negative natural log of the FDR values plotted against the base 2 log of the change for each protein. The thresholds are set for a base log 2 > 0.5 and FDR p value < 0.05; n = 3 IPF specimens. Purple dots indicate known proteins expressed in alveoli, green dots indicate known proteins expressed in blood vessels, blue dots represent matrisome-associated proteins, and red dots represent core-matrisome proteins

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