Proteomic approaches for characterizing renal cell carcinoma

Clark, David J.; Zhang, Hui

doi:10.1186/s12014-020-09291-w

Clinical Proteomics

Table 1 Proteins commonly identified as overexpressed in RCC tissues, plasma, serum, urine, or other biological sources

From: Proteomic approaches for characterizing renal cell carcinoma

Protein accession	Gene name	Protein name	Biological source	GO annotation^a	Citing report
P04075	ALDOA	Fructose-bisphosphate aldolase A	T	Canonical glycolysis; actin filament organization	[20, 42, 49]
P05062	ALDOB	Fructose-bisphosphate aldolase B	T,S	Canonical glycolysis	[42, 80]
P09972	ALDOC	Fructose-bisphosphate aldolase C	T	Canonical glycolysis; epithelial cell differentiation	[20, 40, 42]
P04083	ANXA1	Annexin A1	T,S,U	Actin cytoskeleton organization; adaptive immune response	[20, 80, 93]
P07355	ANXA2	Annexin A2	T,U	Angiogenesis	[20, 26, 32, 93]
Q6P452	ANXA4	Annexin A4	T,O	Negative regulation of coagulation	[20, 26, 29, 37, 40, 42, 103, 118]
P52566	ARHGDIB	Rho GDP-dissociation inhibitor 2	T,U	Cellular response to redox state	[63, 93, 119]
P31146	CORO1A	Coronin-1A	T,U	Actin cytoskeleton organization; calcium ion transport	[20, 37, 42, 119]
P02511	CRYAB	Alpha-crystalline B chain	T	Apoptotic process involved in morphogenesis	[20, 28, 30, 40]
P06733	ENO1	Alpha enolase	T	Canonical glycolysis	[28, 41, 42, 64]
P09104	ENO2	Enolase 2	T,O	Canonical glycolysis	[20, 26, 29, 37, 42, 63, 103]
O15540	FABP7	Fatty acid-binding protein, brain	T	Epithelial cell proliferation; triglyceride catabolic process	[26, 27, 37, 40, 61, 63]
P02751	FN1	Fibronectin	T,P	Angiogenesis; cell adhesion	[42, 76, 78]
P00738	HP	Haptoglobin	T,S,U	Acute inflammatory response	[64, 79, 92, 93]
P11142	HSPA8	Heat shock cognate 71 kDa protein	T,S	ATP metabolic process; regulation of protein complex stability	[42, 63, 79, 80]
P04792	HSPB1	Heat shock protein beta-1	T	Cellular response to vascular endothelial growth factor stimulus	[26, 41, 64]
P00338	LDHA	l-lactate dehydrogenase A chain	T	Glycolytic process; response to hypoxia	[20, 26, 29, 40,41,42, 118]
P09382	LGALS1	Galectin-1	T,O	Apoptotic process; cellular response to glucose stimulus	[20, 27, 46, 103]
Q92597	NDRG1	Protein NDRG1	T	Cellular response to hypoxia; regulation of apoptotic process	[29, 42, 63]
P40261	NNMT	Nicotinamide N-methyltransferase	T,O	NAD biosynthesis via nicotinamide riboside salvage pathway	[20, 37, 40, 49, 103, 118]
Q01813	PFKP	ATP-dependent 6-phosphofructokinase, platelet type	T	Canonical glycolysis	[20, 37, 42]
P07737	PFN1	Profilin-1	T	Positive regulation of epithelial cell migration	[20, 46, 49]
P14618	PKM	Pyruvate kinase PKM	T,P	Canonical glycolysis; positive regulation of sprouting angiogenesis	[20, 26, 42, 81]
Q99541	PLIN2	Perilipin-2 (Adipose differentiation-related protein)	T	Regulation of lipid metabolic process	[37, 40, 42, 118]
P31949	S100A11	Protein A100-A11	T,U	Negative regulation of DNA replication; neutrophil degranulation	[20, 56, 93]
P06702	S100A9	Protein S100-A9	T,S	Innate immune response; neutrophil degranulation	[20, 42, 44, 80]
P63313	TMSB10	Thymosin beta-10	T	Actin filament organization; regulation of cell migration	[20, 56, 61]
P19320	VCAM1	Vascular cell adhesion protein 1	T,P	Cell adhesion; regulation of immune response	[20, 78, 81]
P08670	VIM	Vimentin	T	Cellular response to interferon-gamma; SMAD protein signal transduction	[20, 29, 40, 42, 62, 63]

T tissue, P plasma, S serum, U urine, O other
^a Subset of Uniprot gene ontology (GO) assigned biological processes (https://www.uniprot.org/)

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ISSN: 1559-0275

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