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Fig. 2 | Clinical Proteomics

Fig. 2

From: Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients

Fig. 2

Proteomic analysis. Gene ontology for the 266 quantified proteins visualized with the STRAP software; a Biological processes b Cellular component. c, d PCA analysis of identified proteins. d Grouping of technical repeats (encircled) are for the majority located together. RA patients are marked red and SpA patients blue. Principle component 2 mainly separates the RA and SpA patients. d Analysis of proteins that contribute to 1st and 2nd components of PCA. Principal component 1 separates samples based on haptoglobin (HP), Fibrinogen beta chain (FGB) and several immunoglobulins (IG) proteins. Principal component 2 separates samples based on inflammatory proteins as Myeloperoxidase (MPO), S100-A12 protein (S100A12), Lysozyme C (LYZ), Neutrophil gelatinase-associated lipocalin (LCN2) and Cathepsin G (GTSG). E) Comparison of RA and SpA protein abundances. Gene names are given for a subset of proteins passing p-value < 0.05 as determined by t-test. □: more abundant in RA, : more abundant SpA, +: not significantly changed. f Student-T test of cfDNA concentrations in SF from RA and SpA patients. No significant difference was observed (p-value < 0.05)

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