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Table 2 Correlation Analysis: Synovial fluid proteins identified by mass spectrometry across all RA and SpA samples correlating significantly (p-value < 0.05) to synovial fluid cfDNA

From: Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients

UPID Protein name Gene name R p-value NETs
P62805 Histone H4 HIST1H4A 0.9170 1.52E−06 +
P14780 Matrix metalloproteinase-9 MMP9 0.8141 4.02E−06 +
P80188 Neutrophil gelatinase-associated lipocalin LCN2 0.7925 3.88E−08 +
P07900 Heat shock protein HSP 90-alpha HSP90AA1 0.7314 4.40E−06  
P37837 Transaldolase TALDO1 0.7292 7.12E−03  
P02788 Lactotransferrin LTF 0.7158 5.62E−10 +
P20160 Azurocidin AZU1 0.7114 4.61E−05 +
Q99880 Histone H2B type 1-L HIST1H2BL 0.7008 1.61E−05 +
P12814 Alpha-actinin-1 ACTN1 0.6964 3.86E−05 +
P61626 Lysozyme C LYZ 0.6946 1.57E−08 +
P24158 Myeloblastin PRTN3 0.6803 4.89E−05 +
P15153 Ras-related C3 botulinum toxin substrate 2 RAC2 0.6803 1.31E−04  
P52566 Rho GDP-dissociation inhibitor 2 ARHGDIB 0.6694 1.25E−03  
P08246 Neutrophil elastase ELANE 0.6660 1.35E−03 +
P05164 Myeloperoxidase MPO 0.6584 4.89E−07 +
P52209 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.6529 4.04E−04  
P0DMV9 Heat shock 70 kDa protein 1B HSPA1B 0.6524 1.35E−03  
P63261 Actin, cytoplasmic 2 ACTG1 0.6419 1.28E−07  
P00558 Phosphoglycerate kinase 1 PGK1 0.6270 3.28E−05  
Q99878 Histone H2A type 1-J HIST1H2AJ 0.6265 1.05E−03 +
P04406 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.6096 3.33E−06  
P06744 Glucose-6-phosphate isomerase GPI 0.6007 3.99E−03  
P12429 Annexin A3 ANXA3 0.5955 2.14E−03  
P08311 Cathepsin G CTSG 0.5944 1.66E−04 +
P06733 Alpha-enolase ENO1 0.5942 1.38E−06 +
P14618 Pyruvate kinase PKM PKM 0.5898 2.15E−06  
P06702 Protein S100-A9 S100A9 0.5857 2.12E−06 +
P07737 Profilin-1 PFN1 0.5778 5.90E−06  
P08670 Vimentin VIM 0.5745 1.58E−05  
P60174 Triosephosphate isomerase TPI1 0.5720 4.09E−04  
P13796 Plastin-2 LCP1 0.5704 5.45E−06 +
Q01518 Adenylyl cyclase-associated protein 1 CAP1 0.5698 1.53E−04  
P09211 Glutathione S-transferase P GSTP1 0.5578 1.67E−03  
P00338 l-Lactate dehydrogenase A chain LDHA 0.5531 4.14E−03  
P04083 Annexin A1 ANXA1 0.5486 1.40E−04  
P01033 Metalloproteinase inhibitor 1 TIMP1 0.5463 3.21E−04  
P26038 Moesin MSN 0.5314 4.19E−04  
P62937 Peptidyl-prolyl cis-trans isomerase A PPIA 0.5142 1.85E−04  
P30740 Leukocyte elastase inhibitor SERPINB1 0.5103 4.34E−02  
P18669 Phosphoglycerate mutase 1 PGAM1 0.5080 3.13E−04  
Q71U36 Tubulin alpha-1A chain TUBA1A 0.4917 1.07E−02  
P22894 Neutrophil collagenase MMP8 0.4728 4.74E−03  
P80511 Protein S100-A12 S100A12 0.4689 5.16E−03  
P63104 14-3-3 protein zeta/delta YWHAZ 0.4675 2.70E−03  
P29401 Transketolase TKT 0.4575 1.58E−03  
P09960 Leukotriene A-4 hydrolase LTA4H 0.4572 3.91E−03  
P23528 Cofilin-1 CFL1 0.4462 1.89E−03  
P68133 Actin, alpha skeletal muscle ACTA1 0.4370 2.01E−02  
P08133 Annexin A6 ANXA6 0.4199 7.79E−03  
P02679 Fibrinogen gamma chain FGG 0.4183 1.34E−03  
P36222 Chitinase-3-like protein 1 CHI3L1 0.4106 7.67E−03  
P12111 Collagen alpha-3(VI) chain COL6A3 0.3898 3.26E−03  
P07195 l-Lactate dehydrogenase B chain LDHB 0.3686 3.19E−02  
P04075 Fructose-bisphosphate aldolase A ALDOA 0.3684 2.94E−02  
P02741 C-reactive protein CRP 0.3470 8.78E−03  
P04003 C4b-binding protein alpha chain C4BPA 0.3119 2.17E−02  
P02763 Alpha-1-acid glycoprotein 1 ORM1 0.3061 2.18E−02  
P02750 Leucine-rich alpha-2-glycoprotein LRG1 0.3046 2.24E−02  
P04040 Catalase CAT 0.2955 2.70E−02  
P07225 Vitamin K-dependent protein S PROS1 0.2941 2.78E−02  
P08603 Complement factor H CFH 0.2883 3.12E−02  
P0DJI8 Serum amyloid A-1 protein SAA1 0.2866 3.56E−02  
P60709 Actin, cytoplasmic 1 ACTB 0.2793 4.09E−02  
P49747 Cartilage oligomeric matrix protein COMP − 0.2706 4.37E−02  
P02751 Fibronectin FN1 − 0.2939 2.79E−02  
Q13790 Apolipoprotein F APOF − 0.4627 3.02E−03  
Q96RL7 Vacuolar protein sorting-associated protein 13A VPS13A − 0.5619 1.23E−02  
Q66K66 Transmembrane protein 198 TMEM198 − 0.5646 2.27E−02