Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients

Birkelund, Svend; Bennike, Tue Bjerg; Kastaniegaard, Kenneth; Lausen, Mads; Poulsen, Thomas Bouet Guldbæk; Kragstrup, Tue Wenzel; Deleuran, Bent Winding; Christiansen, Gunna; Stensballe, Allan

doi:10.1186/s12014-020-09292-9

Clinical Proteomics

Table 2 Correlation Analysis: Synovial fluid proteins identified by mass spectrometry across all RA and SpA samples correlating significantly (p-value < 0.05) to synovial fluid cfDNA

From: Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients

UPID	Protein name	Gene name	R	p-value	NETs
P62805	Histone H4	HIST1H4A	0.9170	1.52E−06	+
P14780	Matrix metalloproteinase-9	MMP9	0.8141	4.02E−06	+
P80188	Neutrophil gelatinase-associated lipocalin	LCN2	0.7925	3.88E−08	+
P07900	Heat shock protein HSP 90-alpha	HSP90AA1	0.7314	4.40E−06
P37837	Transaldolase	TALDO1	0.7292	7.12E−03
P02788	Lactotransferrin	LTF	0.7158	5.62E−10	+
P20160	Azurocidin	AZU1	0.7114	4.61E−05	+
Q99880	Histone H2B type 1-L	HIST1H2BL	0.7008	1.61E−05	+
P12814	Alpha-actinin-1	ACTN1	0.6964	3.86E−05	+
P61626	Lysozyme C	LYZ	0.6946	1.57E−08	+
P24158	Myeloblastin	PRTN3	0.6803	4.89E−05	+
P15153	Ras-related C3 botulinum toxin substrate 2	RAC2	0.6803	1.31E−04
P52566	Rho GDP-dissociation inhibitor 2	ARHGDIB	0.6694	1.25E−03
P08246	Neutrophil elastase	ELANE	0.6660	1.35E−03	+
P05164	Myeloperoxidase	MPO	0.6584	4.89E−07	+
P52209	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.6529	4.04E−04
P0DMV9	Heat shock 70 kDa protein 1B	HSPA1B	0.6524	1.35E−03
P63261	Actin, cytoplasmic 2	ACTG1	0.6419	1.28E−07
P00558	Phosphoglycerate kinase 1	PGK1	0.6270	3.28E−05
Q99878	Histone H2A type 1-J	HIST1H2AJ	0.6265	1.05E−03	+
P04406	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.6096	3.33E−06
P06744	Glucose-6-phosphate isomerase	GPI	0.6007	3.99E−03
P12429	Annexin A3	ANXA3	0.5955	2.14E−03
P08311	Cathepsin G	CTSG	0.5944	1.66E−04	+
P06733	Alpha-enolase	ENO1	0.5942	1.38E−06	+
P14618	Pyruvate kinase PKM	PKM	0.5898	2.15E−06
P06702	Protein S100-A9	S100A9	0.5857	2.12E−06	+
P07737	Profilin-1	PFN1	0.5778	5.90E−06
P08670	Vimentin	VIM	0.5745	1.58E−05
P60174	Triosephosphate isomerase	TPI1	0.5720	4.09E−04
P13796	Plastin-2	LCP1	0.5704	5.45E−06	+
Q01518	Adenylyl cyclase-associated protein 1	CAP1	0.5698	1.53E−04
P09211	Glutathione S-transferase P	GSTP1	0.5578	1.67E−03
P00338	l-Lactate dehydrogenase A chain	LDHA	0.5531	4.14E−03
P04083	Annexin A1	ANXA1	0.5486	1.40E−04
P01033	Metalloproteinase inhibitor 1	TIMP1	0.5463	3.21E−04
P26038	Moesin	MSN	0.5314	4.19E−04
P62937	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.5142	1.85E−04
P30740	Leukocyte elastase inhibitor	SERPINB1	0.5103	4.34E−02
P18669	Phosphoglycerate mutase 1	PGAM1	0.5080	3.13E−04
Q71U36	Tubulin alpha-1A chain	TUBA1A	0.4917	1.07E−02
P22894	Neutrophil collagenase	MMP8	0.4728	4.74E−03
P80511	Protein S100-A12	S100A12	0.4689	5.16E−03
P63104	14-3-3 protein zeta/delta	YWHAZ	0.4675	2.70E−03
P29401	Transketolase	TKT	0.4575	1.58E−03
P09960	Leukotriene A-4 hydrolase	LTA4H	0.4572	3.91E−03
P23528	Cofilin-1	CFL1	0.4462	1.89E−03
P68133	Actin, alpha skeletal muscle	ACTA1	0.4370	2.01E−02
P08133	Annexin A6	ANXA6	0.4199	7.79E−03
P02679	Fibrinogen gamma chain	FGG	0.4183	1.34E−03
P36222	Chitinase-3-like protein 1	CHI3L1	0.4106	7.67E−03
P12111	Collagen alpha-3(VI) chain	COL6A3	0.3898	3.26E−03
P07195	l-Lactate dehydrogenase B chain	LDHB	0.3686	3.19E−02
P04075	Fructose-bisphosphate aldolase A	ALDOA	0.3684	2.94E−02
P02741	C-reactive protein	CRP	0.3470	8.78E−03
P04003	C4b-binding protein alpha chain	C4BPA	0.3119	2.17E−02
P02763	Alpha-1-acid glycoprotein 1	ORM1	0.3061	2.18E−02
P02750	Leucine-rich alpha-2-glycoprotein	LRG1	0.3046	2.24E−02
P04040	Catalase	CAT	0.2955	2.70E−02
P07225	Vitamin K-dependent protein S	PROS1	0.2941	2.78E−02
P08603	Complement factor H	CFH	0.2883	3.12E−02
P0DJI8	Serum amyloid A-1 protein	SAA1	0.2866	3.56E−02
P60709	Actin, cytoplasmic 1	ACTB	0.2793	4.09E−02
P49747	Cartilage oligomeric matrix protein	COMP	− 0.2706	4.37E−02
P02751	Fibronectin	FN1	− 0.2939	2.79E−02
Q13790	Apolipoprotein F	APOF	− 0.4627	3.02E−03
Q96RL7	Vacuolar protein sorting-associated protein 13A	VPS13A	− 0.5619	1.23E−02
Q66K66	Transmembrane protein 198	TMEM198	− 0.5646	2.27E−02

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ISSN: 1559-0275

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