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Table 4 SF proteins identified by proteomics with statistically significant correlation (p-value < 0.05) to plasma CRP

From: Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients

UPID Protein name Gene name R p value
P0DJI8 Serum amyloid A-1 protein* SAA1 0.7254 5.47E−10
P02741 C-reactive protein* CRP 0.7148 6.12E−10
P02750 Leucine-rich alpha-2-glycoprotein* LRG1 0.5769 3.26E−06
P02679 Fibrinogen gamma chain* FGG 0.5399 1.75E−05
Q7Z4H8 KDEL motif-containing protein 2 KDELC2 0.4856 4.82E−02
P18428 Lipopolysaccharide-binding protein LBP 0.4765 2.05E−04
P07225 Vitamin K-dependent protein S* PROS1 0.4328 8.64E−04
Q06033 Inter-alpha-trypsin inhibitor heavy chain H3 ITIH3 0.4321 9.85E−04
P00751 Complement factor B CFB 0.4182 1.34E−03
P02671 Fibrinogen alpha chain FGA 0.3954 2.56E−03
P06702 Protein S100-A9* S100A9 0.3913 2.86E−03
P02748 Complement component C9 C9 0.3893 3.02E−03
P01011 Alpha-1-antichymotrypsin SERPINA3 0.3868 3.23E−03
P01009 Alpha-1-antitrypsin SERPINA1 0.3865 3.26E−03
P68133 Actin, alpha skeletal muscle* ACTA1 0.3791 4.66E−02
P02743 Serum amyloid P-component APCS 0.3657 6.03E−03
P08603 Complement factor H* CFH 0.3298 1.30E−02
P36222 Chitinase-3-like protein 1* CHI3L1 0.3170 4.34E−02
P02788 Lactotransferrin* LTF 0.3042 2.26E−02
P05156 Complement factor I CFI 0.2866 3.23E−02
P04003 C4b-binding protein alpha chain* C4BPA 0.2727 4.60E−02
Q14624 Inter-alpha-trypsin inhibitor heavy chain H4 ITIH4 0.2683 4.56E−02
P27169 Serum paraoxonase/arylesterase 1 PON1 − 0.2719 4.27E−02
P02753 Retinol-binding protein 4 RBP4 − 0.2900 3.02E−02
P05452 Tetranectin CLEC3B − 0.2923 2.88E−02
P02656 Apolipoprotein C-III APOC3 − 0.2934 2.82E−02
Q92954 Proteoglycan 4 PRG4 − 0.2970 2.62E−02
P01871 Ig mu chain C region IGHM − 0.2997 2.48E−02
P19823 Inter-alpha-trypsin inhibitor heavy chain H2 ITIH2 − 0.3006 2.44E−02
P19827 Inter-alpha-trypsin inhibitor heavy chain H1 ITIH1 − 0.3293 1.32E−02
P02751 Fibronectin* FN1 − 0.3301 1.30E−02
P22352 Glutathione peroxidase 3 GPX3 − 0.3325 2.74E−02
P02647 Apolipoprotein A-I APOA1 − 0.3343 1.18E−02
P43652 Afamin AFM − 0.3650 5.67E−03
P02787 Transferrin TF − 0.3669 5.41E−03
P05154 Plasma serine protease inhibitor SERPINA5 − 0.3706 9.51E−03
P06396 Gelsolin GSN − 0.3730 4.63E−03
P02768 Albumin ALB − 0.4892 1.30E−04
Q96PD5 N-Acetylmuramoyl-L-alanine amidase PGLYRP2 − 0.5021 8.06E−05
P02766 Transthyretin TTR − 0.5277 2.93E−05
P29622 Kallistatin SERPINA4 − 0.5492 1.17E−05
  1. Proteins marked with * are also positive correlated to SF cfDNA