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Fig. 6 | Clinical Proteomics

Fig. 6

From: CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis

Fig. 6

The CSF EV proteome in ALS. a Volcano plot of the CSF EV proteome in ALS (n = 12, first visit samples only) compared with healthy control subjects (n = 5). Highlighted points indicate FDR-adjusted p < 0.1. Negative log fold change indicates proteins downregulated in ALS compared with controls. Dotted lines indicate p < 0.01 and log2 fold change ± 0.5. b Volcano plot of Gene Ontology (GO) terms by gene set enrichment analysis, ordered by the product of -log10 p-value and fold change. GO terms with FDR-adjusted p < 0.1 labelled. c Volcano plot of GO overrepresentation analysis of proteins upregulated or downregulated in ALS compared with healthy controls, p < 0.05 and log fold change > 0.5 or < − 0.5 compared with healthy controls. Selected GO terms labelled. d Volcano plot of proteomic analysis data, proteins annotated to “proteasome core complex” labelled and highlighted. ALS: amyotrophic lateral sclerosis; EV: extracellular vesicle; CSF: cerebrospinal fluid; HC: healthy control; BLMH: Bleomycin hydrolase (UniProt Q13867); PSMA: Proteasome alpha subunit (PSMA4—P25789; PSMA5—P28066; PSMA6—P60900; PSMA7—O14818); PSMB: Proteasome beta subunit (PSMB1—P20618; PSMB2—P49721; PSMB3—P49720; PSMB6—P28072); GO: Gene ontology

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