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Fig. 7 | Clinical Proteomics

Fig. 7

From: CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis

Fig. 7

a Volcano plot of the CSF EV proteome in C9orf72 ALS (n = 3) compared with non-C9orf72 ALS subjects (n = 9, first-visit samples only). Red points indicate FDR-adjusted p < 0.1, higher in non-C9orf72 ALS, blue points FDR-adjusted p < 0.1 higher in C9orf72 ALS. Negative log fold change indicates proteins downregulated in non-C9orf72 ALS compared with C9orf72 ALS. Dotted lines indicate p < 0.01 and log2 fold change ± 0.5. b Gene ontology (GO) gene set enrichment analysis of the CSF EV proteome in C9orf72 ALS compared with non-C9orf72 ALS. Representative up- and down-regulated terms labelled. ALS: amyotrophic lateral sclerosis; EV: extracellular vesicle; CSF: cerebrospinal fluid; GO: gene ontology; C9: C9orf72 hexanucleotide repeat expansion-associated ALS; CFL1—UniProt P23528; CYBB—P04839; UBA1—P22314; ANXA11—P50955; GPNMB—Q14956; TAGLN—Q01995; TGM2—P21980; KRT13—P13646

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Clinical Proteomics

ISSN: 1559-0275