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Table 1 Demographic data for the CSF EV cohort

From: CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis

  ALS Healthy control p
All C9orf72+ C9orf72 HC vs ALS C9orf72 + vs non-C9orf72-
N 20 4 16 9
%male 75 50 81 55.6 0.396a 0.248a
Age at sampling, mean ± SD (years) 60.0 ± 10.9 53.0 ± 12.9 61.8 ± 10.1 54.5 ± 12.6 0.258b 0.186b
Age at onset, mean ± SD (years) 57.8 ± 10.7 52.1 ± 12.9 59.2 ± 10.2 0.014b
% bulbar onset 25.0 50.0 12.5 0.136a
Disease progression rate, median [IQR] 0.36 [0.18–0.58] 0.47 [0.26–0.73] 0.33 [0.18–0.55] 0.57b
  1. ALS amyotrophic lateral sclerosis, HC healthy control, SD standard deviation, IQR interquartile range
  2. aFisher exact test, bKruskal–Wallis H test