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Table 1 Demographic data for the CSF EV cohort

From: CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis

 

ALS

Healthy control

p

All

C9orf72+

C9orf72

HC vs ALS

C9orf72 + vs non-C9orf72-

N

20

4

16

9

%male

75

50

81

55.6

0.396a

0.248a

Age at sampling, mean ± SD (years)

60.0 ± 10.9

53.0 ± 12.9

61.8 ± 10.1

54.5 ± 12.6

0.258b

0.186b

Age at onset, mean ± SD (years)

57.8 ± 10.7

52.1 ± 12.9

59.2 ± 10.2

0.014b

% bulbar onset

25.0

50.0

12.5

0.136a

Disease progression rate, median [IQR]

0.36 [0.18–0.58]

0.47 [0.26–0.73]

0.33 [0.18–0.55]

0.57b

  1. ALS amyotrophic lateral sclerosis, HC healthy control, SD standard deviation, IQR interquartile range
  2. aFisher exact test, bKruskal–Wallis H test