ALS | Healthy control | p | ||||
---|---|---|---|---|---|---|
All | C9orf72+ | C9orf72− | HC vs ALS | C9orf72 + vs non-C9orf72- | ||
N | 20 | 4 | 16 | 9 | – | – |
%male | 75 | 50 | 81 | 55.6 | 0.396a | 0.248a |
Age at sampling, mean ± SD (years) | 60.0 ± 10.9 | 53.0 ± 12.9 | 61.8 ± 10.1 | 54.5 ± 12.6 | 0.258b | 0.186b |
Age at onset, mean ± SD (years) | 57.8 ± 10.7 | 52.1 ± 12.9 | 59.2 ± 10.2 | – | – | 0.014b |
% bulbar onset | 25.0 | 50.0 | 12.5 | – | – | 0.136a |
Disease progression rate, median [IQR] | 0.36 [0.18–0.58] | 0.47 [0.26–0.73] | 0.33 [0.18–0.55] | – | – | 0.57b |