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Table 2 Demographic data for CSF EV proteomic analysis

From: CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis

  ALS Healthy control p
All C9orf72+ C9orf72 HC vs ALS C9orf72 + vs non-C9orf72
N 12 3 9 5
%male 66.7 33.3 77.8 20 0.131a 0.236a
Age at sampling, mean ± SD (years) 68.1 ± 12.0 51.9 ± 15.6 65 ± 10.0 52.0 ± 14.8 0.113b 0.166b
Age at onset, mean ± SD (years) 59.7 ± 12.4 51.0 ± 15.6 62.6 ± 10.7 0.229b
% bulbar onset 50.0 66.7 44.4 0.545a
Disease progression rate, median [IQR] 0.53 [0.21–0.63] 0.62 [0.37–0.83] 0.51 [0.22–0.60] 0.782b
  1. ALS amyotrophic lateral sclerosis, HC healthy control, SD standard deviation, IQR interquartile range
  2. aFisher exact test. bKruskal–Wallis H test