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Table 1 Univariate logistic analysis for peritoneal metastasis of gastric cancer

From: A nomogram based on glycomic biomarkers in serum and clinicopathological characteristics for evaluating the risk of peritoneal metastasis in gastric cancer

 

Gastric cancer patients

P

Total: n = 129 (%)

No PM: n = 86 (%)

PM: n = 43 (%)

Age

 Mean(min–max)

 

29–84 (59.0)

32–81 (59.5)

0.32

  ≤ 60

65 (50)

46 (53)

19 (44)

 

  > 60

64 (50)

40 (47)

24 (56)

 

Gender

0.24

 Male

84 (65)

59 (69)

25 (58)

 

 Female

45 (35)

27 (31)

18 (42)

 

Weight loss

0.001

 No change

84 (65)

64 (74)

20 (47)

 

 < 5 kg

29 (22)

17 (20)

12 (27)

 

  ≥ 5 kg

16 (12)

5 (6)

11 (26)

 

Tumor location

0.008

 Upper 1/3

20 (16)

13 (15)

7 (16)

 

 Middle 1/3

38 (29)

24 (28)

14 (33)

 

 Lower 1/3

57 (44)

45 (52)

12 (27)

 

 Mixed

13 (10)

4 (5)

9 (22)

 

 Othersa

1 (1)

0 (0)

1 (2)

 

Tumor size

0.001

 Mean (min–max)

 

0.5–14 (3.5)

1–16 (5.9)

 

  < 3 cm

47 (36)

40 (47)

7 (16)

 

  ≥ 3 cm

82 (64)

46 (53)

36 (84)

 

Histology type

0.007

 Adenocarcinoma

49 (38)

41 (48)

8 (19)

 

 Others

74 (57)

45 (52)

29 (67)

 

 Data absent

6 (5)

0 (0)

6 (14)

 

Differentiation

0.004

 High + moderate

18 (14)

18 (21)

0 (0)

 

 Poor

105 (81)

68 (79)

37 (86)

 

 Data absent

6 (5)

0 (0)

6 (14)

 

Lauren classification

0.008

 Intestinal

34 (26)

30 (35)

4 (9)

 

 Diffuse

41 (32)

23 (27)

18 (42)

 

 Mixed

46 (36)

29 (34)

17 (37)

 

 Data absent

8 (6)

4 (5)

4 (9)

 

CEA

0.08

  Mean (min–max)

 

0.2–55.9 (3.4)

0.4–372.8 (17.4)

 

   < 5 ng/mL

105 (81)

73 (85)

32 (74)

 

  ≥ 5 ng/mL

22 (17)

11 (13)

11 (26)

 

  Data absent

2 (2)

2 (2)

0 (0)

 

CA19-9

< 0.001

  Mean (min–max)

 

0.6–2501 (41.9)

0.6–1000 (437.4)

 

    < 37 U/mL

105 (81)

80 (93)

25 (58)

 

   ≥ 37 U/mL

21 (16)

6 (7)

15 (35)

 

   Data absent

3 (2)

0 ()

3 (7)

 

CA125

< 0.001

  Mean (min–max)

 

3.4–49.1 (13.0)

7.5–129.3 (35.2)

 

   < 35 U/mL

101 (78)

76 (88)

25 (58)

 

   ≥ 35 U/mL

19 (15)

6 (7)

13 (30)

 

   Data absent

9 (7)

4 (5)

5 (12)

 

CA724

0.002

  Mean (min–max)

 

0.8–84.6 (5.9)

0.9–300 (34.9)

 

   < 10 U/mL

88 (68)

68 (79)

20 (47)

 

   ≥ 10 U/mL

26 (20)

12 (14)

14 (33)

 

   Data absent

15 (12)

6 (7)

9 (20)

 

AFP

0.16

  Mean (min–max)

 

0.2–11.5 (2.4)

1–15.3 (3.8)

 

   < 20 ng/mL

119 (92)

80 (93)

39 (91)

 

   ≥ 20 ng/mL

1 (1)

0 (0)

1 (2)

 

   Data absent

9 (7)

6 (7)

3 (7)

 

Neutrophil count

0.36

 Mean (min–max)

 

1.6–16.2 (3.8)

1.6–7.9 (3.9)

 

  < 2.5 * 10–9/L

27 (21)

20 (23)

7 (16)

 

   ≥ 2.5 * 10–9/L

102 (79)

66 (77)

36 (84)

 

Lymphocyte count

0.001

  Mean (min–max)

 

1.1–3.7 (1.79)

0.6–2.7 (1.46)

 

    < 2.0 * 10–9/L

94 (73)

55 (64)

39 (91)

 

   ≥ 2.0 * 10–9/L

35 (27)

31 (36)

4 (9)

 

NLR

0.006

 Mean (min–max)

 

0.7–16.2 (2.4)

0.9–11.3 (2.9)

 

    < 2.0

64 (50)

50 (58)

14 (33)

 

   ≥ 2.0

65 (50)

36 (42)

29 (67)

 

Haemoglobin

0.003

 Mean (min–max)

 

52–160 (126.2)

74–159 (113.7)

 

   < 133 g/L

79 (61)

45 (52)

34 (79)

 

   ≥ 133 g/L

50 (39)

41 (48)

9 (21)

 

Platelet count

0.19

 Mean (min–max)

 

96–419 (233.5)

96–505 (234.4)

 

  < 202 * 10–9/L

43 (33)

32 (37)

11 (26)

 

  ≥ 202 * 10–9/L

86 (67)

54 (63)

32 (74)

 

Albumin

0.009

 Mean (min–max)

 

29–49 (39.6)

30–47 (38.9)

 

   < 37 g/L

38 (29)

19 (22)

19 (44)

 

   ≥ 37 g/L

91 (71)

67 (78)

24 (56)

 

Pre-albumin

< 0.001

 Mean (min–max)

 

0.14–0.42 (0.25)

0.09–0.35 (0.21)

 

   < 0.21 g/L

37 (29)

15 (17)

22 (51)

 

    ≥ 0.21 g/L

92 (71)

71 (83)

21 (49)

 

H6N5L1E1: m/z 2620.93

< 0.001

 Mean (min–max)

 

0.001–0.048 (0.006)

0.002–0.020 (0.007)

 

    < 0.0038

49 (38)

43 (50)

6 (14)

 

    ≥ 0.0038

80 (62)

43 (50)

37 (86)

 

H5N5F1E2: m/z 2650.98

< 0.001

 Mean (min–max)

 

0.001–0.028 (0.003)

0.002–0.013 (0.004)

 

    < 0.0017

33 (26)

32 (37)

1 (2)

 

    ≥ 0.0017

96 (74)

54 (63)

42 (98)

 

H6N5E2: m/z 2666.96

< 0.001

 Mean (min–max)

 

0.004–0.008 (0.003)

0.002–0.010 (0.004)

 

   < 0.0020

42 (33)

39 (45)

3 (7)

 

   ≥ 0.0020

87 (67)

47 (55)

40 (93)

 

H6N5L1E2: m/z 2940.08

< 0.001

 Mean (min–max)

 

0.001–0.073 (0.010)

0.003–0.031 (0.013)

 

  < 0.0062

54 (42)

46 (53)

8 (19)

 

  ≥ 0.0062

75 (58)

40 (47)

35 (81)

 
  1. PM peritoneal metastasis, H hexose, N N-acetylhexosamine, F fucose, L α 2,3-sialic acid, E α 2,6-sialic acid, CA19-9, CA125, CA724 carbohydrate antigen 19-9, 125, and 724; NLR: neutrophil/lymphocyte ratio
  2. P < 0.05 marked in bold font shows statistical significant
  3. aOthers include remnant stomach and anastomotic site