Fig. 1

Protein-protein association network of DS-affinity enriched proteins analyzed with STRING. a The protein network can be primarily clustered into four clusters: chromosome binding (Red: 36 DNA-binding proteins; Gold: seven histone-binding), 28 RNA-binding proteins (Blue), 35 vesicle components (Purple), and 32 cytoskeleton components (Green). b The same network highlighting 82 proteins found in the nucleus (Red, based on GO cellular component) and 17 associated with the mitotic cell cycle (Blue, based on Reactome Pathways). c 35 vesicle component proteins (Green) and 20 vesicle-mediated transport proteins (dark Green), and 12 ribonucleoprotein granule (Blue). These classifications are based on GO Molecular Function, GO Cellular Component, and Reactome Pathways. Minimum required interaction score was set to high confidence (0.700) in the network