Fig. 2

a Heatmap of top 20 enriched pathways and processes identified by Metascape. b The top four protein–protein interaction networks and components identified by MCODE algorithm of Metascape analysis. Red network is most likely involved in cellular response to heat stress, vesicle-mediated transport, and kinase maturation complex 1. Blue network is most likely involved in PID BARD1 pathway, DHX9-ADAR-vigillin-DNA-PK-Ku antigen complex, and Nop56p-associated pre-rRNA complex. Green network is mostly likely involved in mRNA splicing and C complex spliceosome. Purple network is most likely involved in Nop56p-associated pre-rRNA complex, actin-mediated contraction, and actin filament-based movement