Fig. 1

Heatmap of BeneMin baseline proteomics data for 83 participants in all four weight change categories. The dendrograms above and to the left side of the heatmap correspond to the results of hierarchical clustering analysis (HCA) for samples and proteins, respectively (the distance matrix of which was computed using the Euclidean method and clustering using the complete linkage method). The bars below the top dendrogram are coloured according to the type of adjunctive treatment (minocycline vs placebo), gender and category of weight change from baseline measured at follow-up. Heatmap was plotted using the pheatmap R package with row scaling