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Table 1 Statistical comparison of demographic and clinical variables between the four weight change categories

From: Application of SWATH mass spectrometry in the identification of circulating proteins does not predict future weight gain in early psychosis

 

Weight change category

Weight change category

Weight change category

Weight change category

Follow-up weight change cohort with SWATH MS data

P-value

Loss >= 10 kg

Loss >= 3 kg AND < 10 kg

Within 3 kg

Gain >= 3 kg

Cohort

Comparison between 4 categories

Number of participants

4

18

23

38

83

 

Number of days of follow-up since Baseline

391.0 ± 37.0

376.3 ± 18.6

385.5 ± 29.8

388.7 ± 29.8

385.2 ± 28.0

0.563

 Missing

0

0

1

0

1

 

Weight change at follow-up since Baseline (kg)

− 20.4 ± 9.8

− 5.8 ± 2.0

0.4 ± 1.6

10.9 ± 7.8

2.9 ± 10.3

1.9e–15

 Missing

0

0

0

0

0

 

Estimated duration of illness at Baseline (months)

30.0 ± 26.9

13.8 ± 9.3

22.7 ± 18.7

18.6 ± 18.7

19.3 ± 17.4

0.595

 Missing

2

6

5

12

25

 

BeneMin treatment allocation

     

0.852

 Minocycline

1

8

11

19

39

 

 Placebo

3

10

12

19

44

 

 Missing

0

0

0

0

0

 

Age at baseline (years)

31.0 ± 5.9

27.0 ± 6.1

23.9 ± 3.7

25.7 ± 5.5

25.7 ± 5.4

0.099

 Missing

0

0

0

0

0

 

Gender

     

0.543

 Female

1

5

4

13

23

 

 Male

3

13

19

25

60

 

 Missing

0

0

0

0

0

 

Weight at baseline (kg)

110.4 ± 26.2

89.8 ± 23.1

88.6 ± 25.5

83.7 ± 26.0

87.7 ± 25.5

0.223

 Missing

0

0

0

0

0

 

BMI at baseline (kg/m2)

35.0 ± 9.2

29.4 ± 7.3

28.6 ± 6.9

27.6 ± 7.2

28.6 ± 7.3

0.327

 Missing

0

0

0

0

0

 

Ethnic origin

     

0.176

 Asian

1

–

3

3

7

 

 Black

0

2

3

1

6

 

 Oriental

0

1

–

1

2

 

 White

3

14

11

27

55

 

 Mixed

0

–

2

–

2

 

 Other

0

–

–

–

–

 

 Missing

0

1

4

6

11

 

Education (years)

13.8 ± 2.5

13.4 ± 2.3

13.1 ± 1.7

12.9 ± 2.1

13.1 ± 2.0

0.681

Missing

0

2

3

8

13

 

Number of participants

4

18

23

38

83

 

Generation of antipsychotic medication at baseline

     

0.093

 First

1

0

0

2

3

 

 Second

3

17

23

36

79

 

 First and Second

0

1

0

0

1

 

 Missing

0

0

0

0

0

 

Generation of antipsychotic medication at follow-up

     

0.712

 First

0

0

0

1

1

 

 Second

4

16

22

36

78

 

 First and Second

0

2

1

1

4

 

 Missing

0

0

0

0

0

 

Baseline PANSS

      

 Positive

20.8 ± 5.3

16.1 ± 4.4

15.8 ± 5.2

16.3 ± 4.8

16.3 ± 4.9

0.384

 Missing

0

0

0

0

0

0.966

 Negative

19.0 ± 8.8

18.1 ± 6.4

16.7 ± 4.1

17.7 ± 5.7

17.5 ± 5.5

0.216

 Missing

0

0

0

0

0

0.300

 General

41.8 ± 12.3

35.3 ± 8.2

32.4 ± 5.6

32.7 ± 8.6

33.6 ± 8.1

 

 Missing

0

0

0

0

0

 

 Total

81.5 ± 25.8

69.5 ± 14.5

64.9 ± 10.5

66.7 ± 16.6

67.5 ± 15.3

 

 Missing

0

0

0

0

0

 

Baseline Premorbid IQ (WTAR)

100.3 ± 12.0

101.6 ± 11.5

101.9 ± 10.8

103.3 ± 10.1

102.4 ± 10.5

0.909

 Missing

0

0

0

1

1

 

Baseline Current IQ (short WAIS-III)

103.3 ± 20.8

97.4 ± 14.3

95.3 ± 18.2

89.6 ± 13.4

93.6 ± 15.6

0.147

 Missing

0

0

0

0

0

 

Baseline CDSS

7.3 ± 6.3

6.8 ± 4.9

4.5 ± 4.0

6.1 ± 4.9

5.8 ± 4.7

0.419

 Missing

0

0

0

0

0

 

Baseline GAF

50.0 ± 14.1

54.3 ± 7.6

58.6 ± 8.7

56.3 ± 10.7

56.2 ± 9.8

0.305

 Missing

0

0

0

0

0

 
  1. Statistical analysis of demographic and clinical variables for 83 participants with available SWATH MS proteomics data, in four follow-up weight change categories Loss >= 10 kg, Loss >= 3 kg AND < 10 kg, Within 3 kg, and Gain >= 3 kg, and the entire cohort. (Measurements of continuous variables are shown as mean ± standard deviation. P-values correspond to the statistical comparison between the distribution of variables in the four weight change categories. P-values < 0.05 indicate statistically significant differences between the compared groups.)
  2. BMI: Body mass index; CDSS: Calgary Depression Scale for Schizophrenia; GAF: Global Assessment of Functioning; IQ: Intelligence Quotient; PANSS: Positive and Negative Syndrome Scale; SWATH MS: Sequential window acquisition of all theoretical fragment ion spectra Mass Spectrometry; WAIS: Wechsler Adult Intelligence Scale; WTAR: Wechsler Test of Adult Reading