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Fig. 4 | Clinical Proteomics

Fig. 4

From: Comparative analysis of differentially abundant proteins quantified by LC–MS/MS between flash frozen and laser microdissected OCT-embedded breast tumor samples

Fig. 4

Analysis of common proteins and GO terms between FF/HOM and OCT/LMD comparisons. ac Common proteins and df common GO terms. a Venn diagram showing the overlap of 216 and 171 significant proteins differentially expressed in FF/HOM vs. OCT/LMD-T and FF/HOM vs. OCT/LMD-TS, respectively. Only proteins with adj. p-value < 0.05 and |log2 FC|> 1 were considered significant. b PCA analysis using 138 common significant proteins from a. c Heat map using unsupervised clustering analysis with 138 common significant proteins identified in a. Each column represents one sample, each row represents a common significant protein. d Venn diagram showing the overlap of 402 and 60 significant GO terms differentially expressed in FF/HOM vs. OCT/LMD-T and FF/HOM vs. OCT/LMD-TS, respectively. Only GO terms with adj. p-value < 0.2 were considered significant. e PCA analysis using 50 common significant GO terms from d. f Heat map using unsupervised clustering analysis with 50 common significant GO terms identified in d. Each column represents one sample, each row represents a common significant GO term. LA, luminal A; LB1, luminal B1

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